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Introduction: Telomere length (TL) is generally regarded as a biomarker of aging. TL, which is influenced by sociodemographic factors, has been shown to be inversely associated with morbidity. However, most studies examined the youngest, and whether the findings can be extended to older individuals is less clear. Further, few studies have examined these questions in Chinese older adults. This cross-sectional study examined TL and its associated factors in Chinese aged 75+ years in Hong Kong.
Methods: Participants were from the Mr. and Ms. Osteoporosis cohort. A structured interview on sociodemographic factors and physical measurement was conducted. Frailty and sarcopenia status were respectively determined by Fried's criteria and the Asian Working Group for Sarcopenia definition. TL was measured by a molecular inversion probe-quantitative PCR assay and expressed as a novel telomere/a single copy reference gene (T/S) ratio. Adjusted binary logistic regressions were used to examine the associations between TL and the presence of multimorbidity, age-related diseases, frailty, and sarcopenia.
Results: Among 555 participants (mean age 83.6 ± 3.8 years, 41.3% females), the mean T/S ratio was 1.01 ± 0.20. Males had a lower T/S ratio (0.97 ± 0.20) compared with females (1.07 ± 0.18) (p < 0.001). A lower education level was related to a longer TL (p = 0.016). Being a current smoker was related to a shorter TL (p = 0.007). TL was not significantly different across categories of age, subjective socioeconomic status, drinking status, physical activity level, and body mass index (p > 0.05). There were no associations between TL and the presence of multimorbidity, diabetes, stroke, cardiovascular diseases, cognitive impairment, frailty, and sarcopenia.
Conclusion: Among Chinese aged 75+ years, males had shorter TL compared with females. TL was not associated with age-related diseases, frailty, and sarcopenia in this age group. TL may not be a biological marker of aging among older individuals.
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http://dx.doi.org/10.1159/000534644 | DOI Listing |
Mol Genet Genomics
December 2024
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen Yang Road, Shanghai, 200031, China.
Low-frequency non-syndromic hearing loss (LFNSHL) is a rare auditory disorder affecting frequencies ≤ 2000 Hz. To elucidate its genetic basis, we conducted whole-exome sequencing on nine Chinese families (31 affected individuals) with LFNSHL. Four heterozygous pathogenic variants, including two novel variants, were identified in common LFNSHL-related genes (WFS1, DIAPH1) and less common genes (TNC, EYA4), achieving a 44% genetic diagnosis rate.
View Article and Find Full Text PDFFront Public Health
December 2024
Institute of Agricultural Economics and Development, Chinese Academy of Agricultural Sciences, Beijing, China.
Introduction: Common prosperity holds significant importance in ensuring social equity, promoting sustainable economic growth, and achieving long-term national security. The management of multidimensional relative poverty is a crucial pathway to realizing the common prosperity of all individuals. It is worthwhile to investigate whether the formal and informal financial involvement of rural households can synergistically alleviate multidimensional relative poverty, ultimately contributing to the realization of common prosperity.
View Article and Find Full Text PDFFront Public Health
December 2024
Department of Nursing, Harbin Medical University, Harbin, China.
Objective: This study investigates the factors influencing sedentary behavior in older adult Chinese stroke patients using decision trees and logistic regression models.
Methods: Convenience sampling method was employed to enroll 346 respondents aged ≥60 years with stroke from the Department of Neurology of three tertiary-level A hospitals in Heilongjiang province, based on the inclusion criteria. The Sedentary Behavior Questionnaire for Older Adults, the International Physical Activity Questionnaire Short Form (IPAQ-S), the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Depression Scale (SDS), and the Social Support Scale (SSRS) were used to assess sedentary behavior, physical activity level, sleep quality, depressive symptoms, and social support, respectively.
Front Public Health
December 2024
Belt and Road Initiative Center for Chinese-European Studies (BRICCES), Guangdong University of Petrochemical Technology, Maoming, China.
The purpose of the study is to determine the impact of hazardous psychosocial factors on stress among employees when performing production tasks to develop recommendations for reducing their impact. Based on the recommendations of the ISO 45003:2021 standard, a special questionnaire was developed to determine hazardous psychosocial factors that lead to the appearance of worker's stress, the answers to which were evaluated on a Likert scale with points from 0 to 4. 68 workers (23 men and 45 women) aged 20 to 45 took part in the survey conducted at industrial enterprises of the Dnipro region in May-June 2023.
View Article and Find Full Text PDFAm J Prev Cardiol
March 2025
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Objective: Secondhand smoke (SHS) is a strong but comparatively controllable cardiometabolic risk factor. This study aims to assess the present and future burden of cardiometabolic diseases (CMDs) from SHS exposure.
Methods: Using the Global Burden of Disease (GBD) framework, we examined mortality and disability-adjusted life year (DALY) from CMDs attributable to SHS, by age, sex, and year, including cardiovascular disease [CVD, ischemic heart disease (IHD) and/or stroke], and/or Type 2 Diabetes Mellitus (T2DM) from 1990 to 2019.
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