In this issue of Neuron, Essayan-Perez and Südhof demonstrate roles for γ-secretase in the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase activity increases synapse formation but decreases neurotransmission (i.e., the probability of presynaptic release), likely due to impairment of cholesterol metabolism.
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| http://dx.doi.org/10.1016/j.neuron.2023.09.021 | DOI Listing |
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