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SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.
Acta Biochim Biophys Sin (Shanghai)
August 2024
Center for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Article Synopsis
- Sun5, a testis-specific gene, is linked to acephalic spermatozoa syndrome (ASS) and plays a critical role in mRNA export in male germ cells.* -
- Knockout mice studies show that loss of Sun5 leads to accumulation of poly(A) RNA in nuclei, resulting in lower sperm counts and motility issues.* -
- Sun5 interacts with proteins like Nxf1 and Nup93, and disruption in this interaction impairs mRNA export, potentially explaining abnormal sperm development in affected mice.*
Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy.
Toxicol In Vitro
August 2024
Department of Urology section, Dalian Friendship Hospital, Dalian, Liaoning 116001, China. Electronic address:
Objective: This study aims to investigate the functional interplay between transcription factor YY1 and nucleoporin 93 (NUP93) in regulating the malignancy of bladder cancer cells.
Methods: NUP93 expressions in bladder cancer tissues and normal counterparts were analyzed using a public dataset and clinical samples. NUP93 and Yin Yang 1 (YY1) mRNA expression and protein levels in T24 and RT4 cells were determined by Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting.
A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
EMBO J
June 2024
Department of Cellular Logistics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Nuclear pore complex (NPC) biogenesis is a still enigmatic example of protein self-assembly. We now introduce several cross-reacting anti-Nup nanobodies for imaging intact nuclear pore complexes from frog to human. We also report a simplified assay that directly tracks postmitotic NPC assembly with added fluorophore-labeled anti-Nup nanobodies.
View Article and Find Full Text PDFNucleoporin93 limits Yap activity to prevent endothelial cell senescence.
Aging Cell
April 2024
Department of Physiology and Biophysics, The University of Illinois at Chicago - College of Medicine, Chicago, Illinois, USA.
As the innermost lining of the vasculature, endothelial cells (ECs) are constantly subjected to systemic inflammation and particularly vulnerable to aging. Endothelial health is hence vital to prevent age-related vascular disease. Healthy ECs rely on the proper localization of transcription factors via nuclear pore complexes (NPCs) to govern cellular behavior.
View Article and Find Full Text PDFEndothelial cells (ECs) form the innermost lining of the vasculature and serve a pivotal role in preventing age-related vascular disease. Endothelial health relies on the proper nucleocytoplasmic shuttling of transcription factors via nuclear pore complexes (NPCs). Emerging studies report NPC degradation with natural aging, suggesting impaired nucleocytoplasmic transport in age-related EC dysfunction.
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