Cushing's syndrome of the orbit: congestive orbitopathy and optic neuropathy associated with steroids.

Orbit

Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Published: October 2023

AI Article Synopsis

  • A 56-year-old female with a history of long-term steroid use for asthma experienced symptoms like orbital congestion and optic neuropathy.
  • Despite extensive laboratory tests and a biopsy that showed unremarkable results, neuroimaging revealed increased orbital fat, leading to a diagnosis of iatrogenic Cushing's syndrome.
  • Early literature considered this condition benign, but recent cases indicate it may be more serious and diagnosed later, leading to potential delays in treatment.

Article Abstract

A 56-year-old female with a history of chronic systemic steroid use for asthma control displayed orbital congestion, exophthalmos, a mild abduction deficit, and optic neuropathy. Laboratory workup was unrevealing. Neuroimaging showed increased orbital fat compartments, though the orbital fat was unremarkable on biopsy. The patient was diagnosed with iatrogenic Cushing's syndrome of the orbit and underwent orbital decompression. Early published literature declared this orbitopathy benign. However, newer cases describe more pathologic changes, suggesting the disease is diagnosed later and/or treatment is delayed.

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Source
http://dx.doi.org/10.1080/01676830.2023.2268158DOI Listing

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