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Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration.
Circulation
January 2025
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA (N.V., R.T.L.).
This editorial refers to “Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration” by Liu . and “YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division” by Morikawa
View Article and Find Full Text PDFEditorial: PIVKA-II Facilitates Risk Stratification for HCC Following HCV Cure-Authors' Reply.
Aliment Pharmacol Ther
December 2024
Department of Medical Sciences, Liver Unit, University of Turin, Turin, Italy.
Prolonged survival by combination treatment with a standardized herbal extract from Japanese Kampo-medicine (Juzentaihoto) and gemcitabine in an orthotopic transplantation pancreatic cancer model.
Front Oncol
December 2024
Clinic for Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its poor prognosis. Traditional Japanese herbal medicine (Kampo), such as Juzentaihoto (a standardized combination of 10 herbal extracts), has shown immune modulatory effects, modulation of microcirculation, and amelioration of fatigue. It is administered to patients to prevent deterioration of cachexia and counteract side effects of chemotherapy.
View Article and Find Full Text PDFAnticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models.
Front Cell Dev Biol
December 2024
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Changes to the composition of the microbiome in neoplasia, is termed oncobiosis, may affect tumor behavior through the changes to the secretion of bacterial metabolites. In this study we show, that ursodeoxycholic acid (UDCA), a bacterial metabolite, has cytostatic properties in pancreatic adenocarcinoma cell (PDAC) models. UDCA in concentrations corresponding to the human serum reference range suppressed PDAC cell proliferation.
View Article and Find Full Text PDFReference ranges for complete blood count in children and adolescents with Down syndrome.
Front Pediatr
December 2024
Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Introduction: Down syndrome (DS) is linked to unique hematopoietic characteristics that affect complete blood count (CBC) parameters. Accurate reference ranges are essential for proper CBC interpretation in this population.
Methods: This retrospective study analyzed 2,627 CBCs from 481 DS patients, aged 31 days to 18 years, at a tertiary care center in Italy.
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