The past two decades have seen a worldwide resurgence in infections caused by () subsp. , the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation "the stealth pathogen." There are many hurdles to studying syphilis pathogenesis, most notably the difficulty of culturing and genetically manipulating , as well as the absence of an effective vaccine for prevention. infection in humans is a complex and lengthy process. In this study, we investigated the invasion process and the function of the infection-dependent antigen Tp0971 as an immunogen to inhibit the dissemination of in an animal infection model. This enables a better understanding of the specific pathogenic mechanism of this pathogen, syphilis pathogenesis, and vaccine research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714829 | PMC |
| http://dx.doi.org/10.1128/spectrum.00047-23 | DOI Listing |
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