By analyzing the impact of aberration in an extreme ultraviolet lithography projector on the imaging indicators of the test patterns for a contact layer in a 5 nm technology node, this paper establishes a mathematical aberration model based on the back propagating neutral network. On the basis of an aberration model, a method for estimating the aberration budget is proposed, which can help reduce the difficulty of achieving imaging performance thresholds in actual production. The performance of the results given by this method is verified by using a rigorous simulation. The results show that the model is highly accurate in predicting an aberration distribution that meets the requirements through an inverse sensitivity analysis and can calculate the wavefront aberration margin based on imaging indicators.
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http://dx.doi.org/10.1364/AO.496461 | DOI Listing |
The model-based method can measure phase aberration without special wavefront detectors. However, the influence of non-uniform beam intensity distribution was not considered, leading to non-negligible system errors. Moreover, no experiments were employed to verify its capability and practicability in atmospheric turbulence.
View Article and Find Full Text PDFNat Commun
July 2024
Department of Electrical and Computer Engineering, Technion, Haifa, Israel.
Wavefront-shaping is a promising approach for imaging fluorescent targets deep inside scattering tissue despite strong aberrations. It enables focusing an incoming illumination into a single spot inside tissue, as well as correcting the outgoing light scattered from the tissue. Previously, wavefront shaping modulations have been successively estimated using feedback from strong fluorescent beads, which have been manually added to a sample.
View Article and Find Full Text PDFJ Gastrointest Cancer
September 2024
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009, Tomsk, Russia.
Background: Rectal cancer (RC) occupies a leading position in the structure of oncological morbidity and mortality. Aberrant methylation of tumor-suppressor genes and hypomethylation of retrotransposons were shown to be detectable in cell-free DNA, circulating in the blood (cfDNA) of cancer patients, indicating the possibility to use them as diagnostic and prognosis markers.
Purpose: Evaluation of the changes in the methylation level of LINE-1 elements and SEPTIN9 and IKZF1 genes in the cell-surface-bound cfDNA (csb-cfDNA) from the blood of RC patients after antitumor therapy at a long-term follow-up.
Sci Adv
January 2024
Saints-Pères Paris Institute for the Neurosciences, CNRS UMR 8003, Université Paris Cité, 45 rue des Saints-Pères, Paris 75006, France.
Aberrations and multiple scattering in biological tissues critically distort light beams into highly complex speckle patterns. In this regard, digital optical phase conjugation (DOPC) is a promising technique enabling in-depth focusing. However, DOPC becomes challenging when using fluorescent guide stars for four main reasons: the low photon budget available, the large spectral bandwidth of the fluorescent signal, the Stokes shift between the emission and the excitation wavelength, and the absence of reference beam preventing holographic measurement.
View Article and Find Full Text PDFBy analyzing the impact of aberration in an extreme ultraviolet lithography projector on the imaging indicators of the test patterns for a contact layer in a 5 nm technology node, this paper establishes a mathematical aberration model based on the back propagating neutral network. On the basis of an aberration model, a method for estimating the aberration budget is proposed, which can help reduce the difficulty of achieving imaging performance thresholds in actual production. The performance of the results given by this method is verified by using a rigorous simulation.
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