We present TWINS (TWo INclining Slits), a method for characterizing phase spatial light modulators (SLMs), inspired by Young interferometry. TWINS is an elegant and versatile approach, using minimal equipment and alignment. It measures phase response locally rather than globally, both horizontally and vertically, with high resolution and at wide angles. It can also measure beam intensity profiles as directly seen by the SLM. TWINS characterizes the anisotropic aberrations in the mainstream models of liquid crystal phase SLMs, which is crucial to improve hologram quality. Compensating for anisotropic aberrations measured by TWINS improved the image quality of planar holograms by 10 dB.
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http://dx.doi.org/10.1364/AO.499387 | DOI Listing |
Minerva Obstet Gynecol
January 2025
Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: Vaginal delivery in twins is feasible but challenging. Successful vaginal delivery of a non-vertex second twin depends on knowledge of specific obstetrical maneuvers. Skill acquisition at the patient's bedside is difficult, making simulation training an integral part of obstetrics and gynecology residency programs.
View Article and Find Full Text PDFHandb Exp Pharmacol
January 2025
Genentech Inc, South San Francisco, CA, USA.
In this chapter, we envision the future of Quantitative Systems Pharmacology (QSP) which integrates closely with emerging data and technologies including advanced analytics, novel experimental technologies, and diverse and larger datasets. Machine learning (ML) and Artificial Intelligence (AI) will increasingly help QSP modelers to find, prepare, integrate, and exploit larger and diverse datasets, as well as build, parameterize, and simulate models. We picture QSP models being applied during all stages of drug discovery and development: During the discovery stages, QSP models predict the early human experience of in silico compounds created by generative AI.
View Article and Find Full Text PDFBackground: Although genetic factors have been identified in the pathogenesis of rheumatoid arthritis (RA), the concordance rate in monozygotic (MZ) twins is low, suggesting that other features contribute to disease development. Further, the relative contribution of such non-genetic elements in identical twins have not been characterized. Here, we aimed to measure differentiating host and microbial biomarkers of RA by studying MZ twins discordant for disease using a multi-omics approach.
View Article and Find Full Text PDFJ Acad Nutr Diet
January 2025
Professor, Institute of Epidemiology and Healthcare, University College London; 1-19 Torrington Place, London, WC1E 7HB.
Introduction: Children's consumption of ultra-processed food (UPF) may contribute to inequalities in obesity and wider health. Socioeconomic patterning in younger UK children's UPF intake is unknown.
Objective: To investigate socioeconomic patterning of UK toddlers' (21-months) and children's (7-years) UPF intake across several household and neighbourhood indicators.
Midwifery
January 2025
School of Health, Education, Policing and Sciences, University of Staffordshire, UK.
Problem: Tongue tie is an added complication when breastfeeding, but little is known about the role tongue tie might play when breastfeeding twins.
Background: Twins are much less likely to be breastfed than singleton babies due to added complications regarding pregnancy, birth and ongoing care. Tongue tie can cause breastfeeding barriers including poor latch, inefficient milk transfer and nipple pain.
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