Background: The purpose of the present study was to investigate the effect of garlic supplementation on androgen levels and glycemic-related markers in patients with PCOS.
Methods: In these 8 weeks of randomized double-blinded control trial, 80 women were randomly assigned into two groups in which patients were asked to intake either 800 mg/day garlic or an identical placebo. A blood sample was obtained pre- and post-trial to assess androgens and glycemic-related parapets. A 3-days- food record and a short form of international physical activity questionnaires (IPAQ) were also evaluated at the beginning and end of the trial.
Results: All participants completed the trial. Garlic supplementation resulted in significant reduction in fasting plasma glucose (-3.22 ± 7.41 vs. 0.72 ± 5.37; = 0.008) and homeostatic model assessment for insulin resistance (HOMA-IR) (-0.29 ± 1.45 vs. 0.28 ± 1.20; = 0.02). In addition, a trend to a significant improvement was detected in free androgen index (FAI) ( = 0.09), insulin levels ( = 0.07), and quantitative insulin sensitivity check index (QUICKI) ( = 0.06). However, no significant difference was found in testosterone and sex hormone-binding globulin (SHBG) ( > 0.05).
Conclusions: Present study indicates that garlic supplementation could be beneficial for FPG and insulin resistance improvement. However, garlic supplementation does not show remarkable efficacy on androgens. Further studies are warranted to confirm the results.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580198 | PMC |
| http://dx.doi.org/10.4103/ijpvm.ijpvm_308_21 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of dietary garlic () and papaya () leaf powder on production performance, ruminal methanogen levels, gut parameters, and meat quality in goats.
Vet World
November 2024
Department of Physiology, University of Veterinary and Animal Sciences, 54000, Lahore, Pakistan.
Background And Aim: Several approaches have been employed to mitigate methane emissions from livestock, with varied results. This study evaluated the effects of shade-dried ground garlic leaf (GL) powder and papaya leaf (PL) powder as crop waste on feed intake, growth performance, ruminal microbial counts, gut epithelial barrier functions, and meat quality in goats.
Materials And Methods: Forty male adult Beetal goats were randomly divided into five treatment groups: (1) Control (basal diet only); (2) basal diet supplemented with 6% bromodichloromethane (BCM); (3) basal diet supplemented with 30% GL powder; (4) basal diet supplemented with 26% PL powder; and (5) basal diet supplemented with 30% GL powder and 26% PL powder (GP).
Optimizing broiler performance, carcass traits, and health: evaluating thyme and/or garlic powders as natural growth promoters in antibiotic-free diets.
Poult Sci
December 2024
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- The study aimed to evaluate the effects of thyme powder (TP), garlic powder (GP), and their combination on broiler chickens, focusing on growth performance, blood health, and carcass quality.
- The experiment involved 264 broiler chicks divided into four groups receiving different dietary treatments, which showed that TP, GP, and their combination significantly improved feed intake, growth rates, and carcass characteristics compared to a control group.
- Notable improvements in immune function and oxidative stress markers were observed, particularly with the combination treatment, suggesting enhanced overall health and the potential of these natural additives as alternatives to antibiotics.
Mitigation of Oxidized Oil Effects on Production Performances and Meat Quality of Broilers by Dietary Supplementation of Allicin.
Life (Basel)
November 2024
Food and Feed Quality Department, National Research and Development Institute for Animal Biology and Nutrition, 077015 Balotesti, IF, Romania.
The objective of this study was to evaluate the effects of dietary oxidized oil and allicin (two different dietary sources) as natural antioxidants on the growth performance and meat quality of broilers. A total of 200 one-day-old Ross 308 broilers were randomly divided into four dietary groups (50 birds/group). The experimental groups (OO-oxidized oil; OOA-oxidized oil and allicin; OOG-oxidized oil and garlic leaves) differed from the control one by the presence of oxidized oil in their dietary structure (peroxide value 9.
View Article and Find Full Text PDFAmeliorating effect of S-Allyl cysteine (Black Garlic) on 6-OHDA mediated neurotoxicity in SH-SY5Y cell line.
Toxicol Rep
December 2024
Faculty of Medicine, Department of Medical Pharmacology, Ataturk University, Erzurum, Turkey.
Therapeutic approaches based on isolated compounds derived from natural products are more common in preventing diseases involving inflammation and oxidative stress at present. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound with many positive effects in cell models and living systems. SAC has biological activity in various fields, enclosing healing in learning and memory disorders, neurotrophic effects, and antioxidant activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!