The objective of this study was to investigate the thromboelastography (TEG) variables and platelet count after Asian pit viper (Gloydius) envenomation in dogs compared with healthy control dogs. Ten dogs with snake envenomation and twenty healthy dogs were included. There was a significant decrease in G (P=0.017), maximum amplitude (MA) (P=0.012), angle value (P=0.041), platelet count (P<0.001, as well as an increase in K value (P=0.034) and R value (P=0.007) in dogs with snake envenomation. The results of this study revealed that dogs with Asian pit viper (Gloydius) envenomation showed a hypocoagulable state compared with healthy dogs. Our findings may support the use of TEG for diagnosing and monitoring coagulopathy after Asian pit viper (Gloydius) envenomation in dogs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686768PMC
http://dx.doi.org/10.1292/jvms.23-0100DOI Listing

Publication Analysis

Top Keywords

asian pit
8
pit viper
8
viper gloydius
8
gloydius envenomation
8
platelet count
8
dogs
5
thromboelastographic evaluation
4
evaluation dogs
4
dogs asian
4
envenomation objective
4

Similar Publications

A genus-wide study on venom proteome variation and phospholipase A inhibition in Asian lance-headed pit vipers (genus: Trimeresurus).

Comp Biochem Physiol C Toxicol Pharmacol

February 2025

Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; School of Medicine, College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, Taiwan; Institute of Bioinformatics and Structural Biology, College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

Article Synopsis
  • The research utilized techniques like SDS-PAGE and LCMS/MS to investigate venom protein variability and identified conserved protein families with diverse expressions that do not follow snake evolutionary lineages.
  • Key findings indicate that while certain enzymes' expression correlates weakly with venom effects, phospholipase A activity strongly correlates with its abundance, and a small molecule inhibitor, varespladib, may effectively inhibit PLA activities, suggesting its potential as a therapeutic for snakebite treatment.
View Article and Find Full Text PDF

Introduction: Achieving an adequate surgical plane through optimal traction is crucial for liver parenchymal transection in minimally invasive liver surgery (MILS). MILS is more technically demanding than open liver surgery because of limited instrument mobility and the inability to use the surgeon's hand, potentially leading to iatrogenic injuries. The Pulley maneuver using barbed sutures has been used for laparoscopic hepatectomy; however, the sutures are single-use and may pass through the liver parenchyma, making it uneconomical and inflexible.

View Article and Find Full Text PDF

Understanding how environmental factors affect the performance of predators can provide profound insights into predator-prey interactions from evolutionary and ecological perspectives and the global distributional patterns of each taxon. Almost all venomous predators are ectotherms, with muscle contraction properties depending on temperature. For predators having venom transportation systems driven by muscle contraction, temperature may have quite large effects on envenomation performance for prey subjugation.

View Article and Find Full Text PDF

Paraspecificity of Mexican antivipmyn TRI antivenom in envenomation by Chinese Protobothrops mangshanensis (Mangshan pit viper) in France: A case report and experimental neutralization of venom procoagulant effect.

Toxicon

August 2024

Département de Biologie Médicale, Hôpital d'instruction des Armées Bégin, 69 Avenue de Paris, 94160, Saint-Mandé, France, UMR-S1144, Université Paris Cité, 4 Avenue de l'observatoire, 75006, Paris, France. Electronic address:

This case report presents an exotic envenomation by a Chinese snake, Protobothrops mangshanensis. Its venom exhibited potent activity against plasma and fibrinogen, among other enzymatic activities. The patient initially presented with edema of the right upper limb, without tissue necrosis.

View Article and Find Full Text PDF

Groundwater implications on methane emission from non-sewered sanitation systems in Nepal.

Environ Pollut

September 2024

Department of Environment Science and Engineering, Kathmandu University, Nepal; Aquatic Ecology Centre, School of Science, Kathmandu University, Nepal.

Non-sewered sanitation systems (NSSS) are identified as significant contributors of greenhouse gases (GHGs), primarily due to biological processes occurring within the containment systems. In unsealed or unlined containment systems like pit latrines, the emissions are influenced by moisture. This work quantified the GHG emission from unlined or unsealed containments prevalent in Nepal and compared it with sealed containment-like septic tanks, where the chances of groundwater (GW) inundation are low.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!