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Accounting for microorganisms yields stricter water quality criteria and elevated ecological risks of antibiotics: A case study of sulfonamides in the Yangtze River Delta.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address:
The derivation of water quality criteria (WQC) for antibiotics is influenced by the inclusion of various organisms' toxicity data, including microbial data, though no definitive conclusions have been reached. This study focuses on sulfonamide antibiotics, common in the Yangtze River Delta (YRD), to assess the influences of different organisms' toxicity data on determining WQCs and subsequent evaluation of ecological risks. A total of 263 toxicity data points from eight sulfonamides, including sulfamethoxazole (SMX) and sulfamethazine (SM2), were selected to derive WQCs using Species Sensitivity Distribution (SSD) methods.
View Article and Find Full Text PDFProcess analysis and multi-parameter optimization of 5052 aluminum alloy FSW based on thermo-mechanical coupling and Taguchi method.
Sci Rep
January 2025
Beijing Solidwel Intelligent Technology Co., Ltd., BeiJing, 100000, China.
Based on the Johnson-Cook constitutive model and modified Coulomb's law, the study investigates the impact of various process parameters on the weld temperature field in high-strength 5052 aluminum alloy friction stir welding (FSW) for aerospace applications. Utilizing a thermo-mechanical model, the significance of rotational speed, welding speed, and indentation on the peak weld temperature is examined through Taguchi's orthogonal experimental design. S/N ratio and ANOVA results show that the rotational speed has the most significant effect on the peak temperature of the weld, followed by the amount of indentation, and the welding speed has the smallest effect, the optimal combination of welding process parameters is determined as follows:the rotational speed is 1000 rpm, the amount of indentation is 0.
View Article and Find Full Text PDFAs one of the most destructive and invasive cancers, pancreatic cancer exhibits complex tumor heterogeneity, which has been a major challenge for clinicians in terms of patient treatment and prognosis. The toll-like receptor (TLR) pathway is closely related to the immune microenvironment within various cancer tissues. To explore the development pattern of pancreatic cancer and find an ideal biomarker, our research has explored the mechanism of the TLR pathway in pancreatic cancer.
View Article and Find Full Text PDFInternational Expert Consensus on Relevant Health and Functioning Concepts to Assess in Users of Tobacco and Nicotine Products: Delphi Study.
JMIR Form Res
January 2025
PMI R&D, Philip Morris Product S.A., Neuchâtel, Switzerland.
Background: A Delphi study was conducted to reach a consensus among international clinical and health care experts on the most important health and functioning self-reported concepts when evaluating a switch from smoking cigarettes to using smoke-free tobacco and/or nicotine products (sf-TNPs).
Objective: The aim of this research was to identify concepts considered important to measure when assessing the health and functioning status of users of tobacco and/or nicotine products.
Methods: Experts (n=105), including health care professionals, researchers, and policy makers, from 26 countries with professional experience and knowledge of sf-TNPs completed a 3-round, adapted Delphi panel.
Concentrations, composition profiles, and in vitro-in silico-based mixture risk assessment of bisphenol A and its analogs in plant-based foods.
Environ Int
December 2024
Institute of Food Safety and Health Risk Assessment, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan. Electronic address:
The substitution of bisphenol A (BPA) with structurally similar analogs has raised concerns due to their comparable estrogenic activities. Considering the high consumption of plant-based foods, assessing the risks posed by bisphenols (BPs) in such dietary sources is essential. However, limited exposure and animal toxicological data on BP analogs hinder comprehensive risk assessments.
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