Electric motors in electric and hybrid vehicles generate mid-frequency noise and vibration. These factors cause drivers to experience discomfort while traveling. Active mounting techniques have been extensively researched and developed to effectively address this issue. The optimal placement of an active mounting system is essential for enhancing NVH performance when an active mounting system is utilized. In order to propose optimal location criteria for active paths, this paper concentrates on developing an analytical model based on both dynamic and static analysis. The secondary forces along active trajectories are mathematically determined when a structure is subjected to an excitation force. These locations are considered optimal for the active mounting system if the secondary forces are comparatively minimal. Simulations and feasibility experiments are also conducted in order to validate the proposed method. In addition, the results are compared with the case of beam structure. It has been determined through this procedure that the active path's control performance will be enhanced if it is positioned in the optimal location and less control force is required than in the case of beam.
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http://dx.doi.org/10.1038/s41598-023-44980-0 | DOI Listing |
Background: Hematoxylin and eosin (H&E) staining is widely considered to be the gold-standard diagnostic tool for histopathology evaluation. However, the fatty nature of some tissue types, such as breast tissue, presents challenges with cryo-sectioning, often resulting in artifacts that can make histopathologic interpretation and correlation with other imaging modalities virtually impossible. We present an optimized on-block H&E staining technique that improves contrast for identifying collagenous stroma during cryo-fluorescence tomography (CFT) sectioning.
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Department of Public Health Leadership and Practice, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Exposure to the United States criminal legal system - whether through contact with law enforcement, incarceration in a jail or prison, or community supervision - is associated with a range of adverse health outcomes. There is mounting evidence that mass incarceration drives health inequities, particularly for Black, Indigenous, and People of Color. However, relative to its outsized impacts on health and health inequities, the criminal legal system has received limited attention in epidemiology.
View Article and Find Full Text PDFJ Appl Lab Med
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Department of Laboratories, Seattle Children's Hospital, Seattle, WA, United States.
Background: As clinical laboratories struggle to maintain their financial footing and as patients face mounting out-of-pocket expenses for diagnostic testing, being able to perform financial analysis of laboratory stewardship efforts has become an increasingly important skill.
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Sci Rep
January 2025
Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu , Tokyo, 183-8509, Japan.
Organoids are stem cell-derived three-dimensional tissue cultures composed of multiple cell types that recapitulate the morphology and functions of their in vivo counterparts. Organ-on-a-chip devices are tiny chips with interconnected wells and channels designed using a perfusion system and microfluidics to precisely mimic the in vivo physiology and mechanical forces experienced by cells in the body. These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future.
View Article and Find Full Text PDFFront Cell Dev Biol
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Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival and quality of life for this patient population, extensive efforts are being made to establish effective therapeutic modalities. New treatment options are needed, it seems.
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