Over the last six decades folded polymer chains-so-called Single Chain Nanoparticles (SCNPs)-have evolved from the mere concept of intramolecularly crosslinked polymer chains to tailored nanoreactors, underpinned by a plethora of techniques and chemistries to tailor and analyze their morphology and function. These monomolecular polymer entities hold critical promise in a wide range of applications. Herein, we highlight the exciting progress that has been made in the field of catalytically active SCNPs in recent years.
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http://dx.doi.org/10.1002/anie.202311734 | DOI Listing |
Angew Chem Int Ed Engl
January 2025
KU Leuven: Katholieke Universiteit Leuven, Chemistry, BELGIUM.
Understanding the impact of oxidative modification on protein structure and functions is essential for developing therapeutic strategies to combat macromolecular damage and cell death. However, selectively inducing oxidative modifications in proteins remains challenging. Herein we demonstrate that [V6O13{(OCH2)3CCH2OH}2]2- (V6-OH) hybrid metal-oxo cluster can be used for selective protein oxidative cleavage and modifications.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Macromolecular Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44122, USA.
Data-driven techniques, such as proper orthogonal decomposition (POD) and uniform manifold approximation & projection (UMAP), are powerful methods for understanding polymer behavior in complex systems that extend beyond ideal conditions. They are based on the principle that low-dimensional behaviors are often embedded within the structure and dynamics of complex systems. Here, the internal motions of a thermoresponsive, LCST polymer are investigated for two cases: (1) the coil-to-globule transition that occurs as the system is heated above its critical temperature and (2) intramolecularly crosslinked, single chain nanoparticles (SCNPs) both above and below the critical temperature ().
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Department of Electrical, Electronics and Communication Engineering, Indian Institute of Technology Dharwad, Karnataka - 580011, India.
Prostate cancer antigen 3 (PCA3) has emerged as a critical biomarker for the early detection of prostate cancer, complementing the traditional prostate-specific antigen (PSA) testing. This research presents a novel resistive sensor based on reduced graphene oxide (RGO) functionalized with glutaraldehyde (GA)/complementary single-stranded DNA (ss-DNA) for the detection of the PCA3 RNA. The device was meticulously characterized at each fabrication step to confirm the successful integration of the various layers on the sensor device, utilizing atomic force microscopy (AFM) which confirmed the increase in the thickness of the sensor from ∼1.
View Article and Find Full Text PDFCurr Rheumatol Rev
January 2025
Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.
Introduction/objectives: Genetic variations could explain individual responses to drugs. This case-control study aimed to investigate the association between the multidrug resistance 1 (MDR1) gene exonic single nucleotide variants (SNVs), rs1128503/C1236T and rs1045642/C3435T, and the response to intravenous methylprednisolone in Egyptian patients with active systemic lupus erythematosus (SLE).
Method: Real-time polymerase chain reaction was used.
ACS Mater Lett
January 2025
Department of Chemistry, Durham University, Durham, DH1 3LE, U.K.
The study of structure-activity relationships is a top priority in the development of nontraditional luminescent materials. In this work, nonconjugated polyurethanes (PUs) with full-color emission (red, green, and blue) are easily obtained by control of the diol monomer structure and the polymerization conditions. Selected diol monomers introduced single, double, or triple bond repeating units into the main chain of the PUs, in order to understand how unsaturated bonds and H-bonds affect their luminescence from a molecular orbital viewpoint.
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