In an article in , Nanayakkara and colleagues assessed the glycemic efficacy and safety of AndroidAPS, an open-source automated delivery (AID) system, in a crossover randomized controlled trial. Although the trial included only 20 participants during a relatively short 4-week intervention period, glycemic outcomes attained were similar to commercial AID systems and there were no safety concerns. Validation of open-source AID systems in studies such as this should help address clinician hesitancy regarding these systems, and affirms the role of patient-centered innovation and self-management in diabetes care.
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http://dx.doi.org/10.1177/19322968231208216 | DOI Listing |
Neurology
January 2025
Department of Neurology, Massachusetts General Hospital, Boston.
Background And Objectives: Rolandic epilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models and healthy controls. Sleep spindles are decreased in RE and related sleep-activated epileptic encephalopathies.
View Article and Find Full Text PDFOMICS
January 2025
OMICS: A Journal of Integrative Biology, New Rochelle, New York, USA.
UN Women is the United Nations "entity dedicated to gender equality and the empowerment of women". UN Women is an example of the institutions of global governance that followed the gender turn in women's rights over the past 2 decades. This opinion commentary unpacks a brief history of UN Women, and the ongoing disparities in gender diversity, equity, and inclusion (DEI) in science, engineering, and medicine, not to mention in science communication, with the aim to shed light on the adverse impacts of gender essentialism and gender binary.
View Article and Find Full Text PDFPrehosp Emerg Care
January 2025
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Objectives: Abusive head trauma (AHT) is a leading cause of death in young children. Analyses of patient characteristics presenting to Emergency Medical Services (EMS) are often limited to structured data fields. Artificial Intelligence (AI) and Large Language Models (LLM) may identify rare presentations like AHT through factors not found in structured data.
View Article and Find Full Text PDFJ Comput Chem
January 2025
Chemistry and Forensic Science, School of Natural Sciences, University of Kent, Canterbury, UK.
Magnesium-containing molecules, including MgCH, MgCH, and MgCH, have been detected in the interstellar medium, largely facilitated by their high dipole moments. However, despite great efforts, MgCH species remain elusive. Given the challenges in obtaining experimental data for these molecules, theoretical studies play a crucial role in guiding their detection.
View Article and Find Full Text PDFUnlabelled: Proteins commonly self-assemble to create liquid or solid condensates with diverse biological activities. The mechanisms of assembly are determined by each protein's sequence and cellular context. We previously developed distributed amphifluoric FRET (DAmFRET) to analyze sequence determinants of self-assembly in cells.
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