Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus SCSIO 41041 and their enzyme inhibiting activity.

Twelve compounds, including eleven bisabolane-type sesquiterpenoids (-), and one bacillibactin () were identified from marine-derived fungus SCSIO 41041 isolated from . The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. Compound displayed significant inhibitory activity against neuraminidase (NA) with an IC value of 24.0 μM, which was equivalent to the positive drug oseltamivir phosphate (IC value of 20.0 μM). And the NA inhibitory activity was confirmed by molecular docking analysis.