AI Article Synopsis
- Researchers designed far-red BODIPY-based oxime esters to release specific carboxylic acid molecules when exposed to low power red LED light.
- The breakdown of the N-O oxime ester bond under light activates the release of these caged compounds, which was analyzed using H NMR spectroscopy for mechanism and kinetics.
- The approach was tested for drug delivery to release valproic acid (VPA) on demand, aiming to trigger apoptosis in tumor cells through this photo-uncaging strategy.
Article Abstract
Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750304 | PMC |
| http://dx.doi.org/10.1039/d3tb01867a | DOI Listing |
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