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Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering. | LitMetric

Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering.

Biodes Res

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA.

Published: April 2020

AI Article Synopsis

Article Abstract

In the last decade, the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome editing. However, this democratized technology is both a boon and a bane, for which we have yet to understand the full potential to investigate and rewrite genomes (also named "genome biodesign"). Rapid CRISPR advances in a range of applications in basic research, agriculture, and clinical applications pose new risks and raise several biosecurity concerns. In such a fast-moving field of research, we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530647PMC
http://dx.doi.org/10.34133/2020/9429650DOI Listing

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