AI Article Synopsis
- Psychological stress may be linked to dementia risk, but the exact mechanisms are not well understood.
- A study involving 73 cognitively healthy middle-aged adults found no significant relationship between self-reported psychological stress and key Alzheimer’s disease biomarkers in cerebrospinal fluid.
- The study noticed small effect sizes in the results and called for further research, especially since participants reported generally low stress levels.
Article Abstract
Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f effect sizes were small in magnitude (f≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578338 | PMC |
| http://dx.doi.org/10.3233/ADR-230052 | DOI Listing |
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