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| http://dx.doi.org/10.1021/acsmedchemlett.3c00382 | DOI Listing |
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Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection.
J Vis Exp
August 2024
Department of Comparative Medicine, Medical University of South Carolina;
The purpose of this protocol is to guide researchers in performing a palpation-guided technique of intra-articular knee injection in guinea pigs and assessment using micro-computed tomography. Dunkin-Hartley guinea pigs are robust models for osteoarthritis research as they spontaneously develop osteoarthritis in their knees. Intra-articular drug delivery is a common method to study the effects of an investigational drug in vivo.
View Article and Find Full Text PDFEstablishing New Isosexual Pairs in Adult Male Guinea Pigs () to Facilitate Social Housing.
J Am Assoc Lab Anim Sci
March 2024
Department of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina;, Email:
Guinea pigs () are a commonly used species in biomedical research. As social creatures, compatible guinea pigs should be housed together unless scientific objectives or veterinary care require otherwise. Extensive literature suggests that adult male guinea pigs are highly aggressive in the presence of females, but data are lacking regarding the compatibility of cohoused adult males in the absence of females.
View Article and Find Full Text PDFStimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma.
Chem Sci
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Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina 70 President St Charleston SC 29425 USA
High-risk neuroblastoma (NB) accounts for 15% of all pediatric cancer deaths. Refractory disease for high-risk NB patients is attributed to chemotherapy resistance and immunotherapy failure. The poor prognosis for high-risk NB patients demonstrates an unmet medical need for the development of new, more efficacious therapeutics.
View Article and Find Full Text PDFSynthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.
Eur J Med Chem
December 2022
Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President St, Charleston, SC, 29425, USA. Electronic address:
The epigenetic regulator lysine specific demethylase 1 (LSD1), a MYCN cofactor, cooperatively silences MYCN suppressor genes. Furthermore, LSD1 has been correlated with adverse effects in neuroblastic tumors by propagating an undifferentiated, malignant phenotype. We observed that high LSD1 mRNA expression in MYCN-expressing neuroblastoma (NB) correlated with poor prognosis, implicating LSD1 as an oncogenic accomplice in high-grade NB.
View Article and Find Full Text PDFIdentification and Characterization of Novel Small-Molecule SMOX Inhibitors.
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Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 70 President St., Charleston, SC 29425, USA.
The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine oxidase that is upregulated during excitotoxic, ischemic, and inflammatory states. In addition to the loss of radical scavenging capabilities associated with spermine depletion, the catabolism of spermine by SMOX results in the production of toxic byproducts, including HO and acrolein, a highly toxic aldehyde with the ability to form adducts with DNA and inactivate vital cellular proteins.
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