AI Article Synopsis
- Filoviridae family viruses, like Ebola and Marburg, cause severe and often deadly hemorrhagic fever in humans and primates, with case fatality rates between 25% and 90%.
- Outbreaks primarily occur in sub-Saharan Africa, raising concerns about their spread from rural to urban areas and the need for robust pandemic preparedness.
- There are still significant scientific gaps in understanding these high-priority pathogens, which this review aims to address by discussing those gaps and potential prototype virus candidates.
Article Abstract
Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg (MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates. Sporadic outbreaks of filovirus disease occur in sub-Saharan Africa with reported case fatality rates ranging from 25% to 90%. The high mortality and increasing frequency and magnitude of recent outbreaks along with the increased potential for spread from rural to urban areas highlight the importance of pandemic preparedness for these viruses. Despite their designation as high-priority pathogens, numerous scientific gaps exist in critical areas. In this review, these gaps and an assessment of potential prototype pathogen candidates are presented for this important virus family.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009505 | PMC |
| http://dx.doi.org/10.1093/infdis/jiad362 | DOI Listing |
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