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Drug development for Alzheimer's disease Is extremely challenging, as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-β cascade hypothesis. More recently, advances in the development of Lecanemab, an anti-amyloid-β monoclonal antibody, have shown positive results in reducing brain A burden and slowing cognitive decline in patients with early- stage Alzheimer's disease in the Phase III clinical trial (Clarity Alzheimer's disease). Despite these promising results, side effects such as amyloid-related imaging abnormalities (ARIA) may limit its usage.
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View Article and Find Full Text PDFArticle Synopsis
- Mild cerebral small vessel disease (CSVD) markers are common but only high CSVD burden increases stroke and dementia risk, potentially identified using a multi-marker CSVD score.
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- The findings suggest that assessing CSVD burden could enhance stroke risk identification, complementing traditional risk assessments like the Framingham Stroke Risk Profile.
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