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Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242. | LitMetric

Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242.

J Antibiot (Tokyo)

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao, 266071, China.

Published: December 2023

AI Article Synopsis

Article Abstract

Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 μg ml.

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Source
http://dx.doi.org/10.1038/s41429-023-00664-5DOI Listing

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