This study presents the results of a network-based analysis of health related quality of life (HRQoL) among Slovenian adolescents. The study aimed to examine the relationship between HRQoL and mental well-being among adolescents of different age and gender groups. A cross-sectional study was conducted from November 2019 to January 2020 in 16 primary and 9 secondary schools in Slovenia. The KIDSCREEN-27 scale was used to collect the data on HRQoL, and the Warwick-Edinburgh Mental Well-being Scale to collect data on mental well-being. We used network model trees to demonstrate differences in psychometric network structure measuring correlations between different concepts in adolescent HRQoL. A total of 2972 students aged 10-19 years participated in the study. The significant split in the network tree (p < 0.001) indicated differences in relations between HRQoL subscale scores and mental well-being score among adolescents younger than 12 years old. In comparison to older adolescents the correlation between mental well-being and mood scores was significantly weaker in this group of the youngest participants (p < 0.001). A network model tree analysis also uncovered an interesting pattern based on gender and age (p < 0.013) where a correlation between mood and family support became weaker for female at the age of 12 and for male at the age of 16. Data mining techniques have recently been used by healthcare researchers and professionals. Network-based analysis is an innovative alternative to classical approaches in HRQoL research. In this study we demonstrate the significant differences in the perceptions of HRQoL and mental well-being among adolescents in different age and gender groups that were discovered using tree-based network analysis.
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http://dx.doi.org/10.1038/s41598-023-44493-w | DOI Listing |
Pharmazie
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
: Major Depressive Disorder (MDD) is a prevalent and debilitating mental disorder that has been linked to hyperhomocysteinemia and folate deficiency. These conditions are influenced by the methylenetetrahydrofolate reductase () gene, which plays a crucial role in converting homocysteine to methionine and is essential for folate metabolism and neurotransmitter synthesis, including serotonin. : This study explored the association between and polymorphisms among Saudi MDD patients attending the Erada Complex for Mental Health and Erada Services outpatient clinic in Jeddah, Saudi Arabia.
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Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly observed. The residual approach has been widely applied to estimate CR, where the degree of resilience is estimated through a linear model's residuals.
View Article and Find Full Text PDFSemin Immunopathol
January 2025
Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
The brain-gut axis constitutes the basis for the bidirectional communication between the central nervous system and the gastrointestinal tract driven by neural, hormonal, metabolic, immunological, and microbial signals. Alterations in the gut microbiome composition as observed in inflammatory bowel diseases can modulate brain function and emerging empirical evidence has indicated that interactions among the brain-gut microbiome-axis seem to play a significant role in the pathogenesis of both inflammatory bowel diseases and psychiatric disorders and their comorbidity. Yet, the immunological and molecular mechanisms underlying the co-occurrence of inflammatory bowel diseases and psychological symptoms are still poorly understood.
View Article and Find Full Text PDFAmbio
January 2025
School of Forest Sciences, University of Eastern Finland, Joensuu, Finland.
Trees offer multiple benefits, including impacts on physical and mental health. In this interdisciplinary study, we explored the relationships humans develop with specific favourite trees based on our survey data (n = 158) collected in the Netherlands. Here, we examined action possibilities (affordances) provided by trees, including immaterial actions, such as memorisation or the enjoyment of beauty.
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Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Caffeine consumption is regarded as a widespread phenomenon, and its usage has continued to increase. In addition, the growing usage of antidepressants worldwide and increase in mental health disorders were shown in recent statistical analyses conducted by the World Health Organisation. The coadministration of caffeine and antidepressants remains a concern due to potential interactions that can alter a patient's response to therapy.
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