Resting-state functional magnetic resonance imaging (rs-fMRI), initially proposed by Biswal et al. in 1995, has emerged as a pivotal facet of neuroimaging research. Its ability to examine brain activity during the resting state without the need for explicit tasks or stimuli has made it an integral component of brain imaging studies. In recent years, rs-fMRI has witnessed substantial growth and found widespread application in the investigation of functional connectivity within the brain. To delineate the developmental trajectory of rs-fMRI over the past two decades, we conducted a comprehensive analysis using bibliometric tool Citespace. Our analysis encompassed publication trends, authorship networks, institutional affiliations, international collaborations, as well as emergent themes in references and keywords. Our study reveals a remarkable increase in the volume of rs-fMRI publications over the past two decades, underscoring the burgeoning interest and potential within this field. Harvard University stands out as the institution with the highest number of research papers published in the realm of RS-fMRI, while the United States holds the highest overall influence in this domain. The recent emergence of keywords such as "machine learning" and "default mode," coupled with citation surges in reference to rs-fMRI, have paved new avenues for research within this field. Our study underscores the critical importance of integrating machine learning techniques into rs-fMRI investigations, offering valuable insights into brain function and disease diagnosis. These findings hold profound significance for the field of neuroscience and may furnish insights for future research employing rs-fMRI as a diagnostic tool for a wide array of neurological disorders, thus emphasizing its pivotal role and potential as a tool for investigating brain functionality.
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http://dx.doi.org/10.1016/j.brainres.2023.148634 | DOI Listing |
Nat Sci Sleep
January 2025
Department of Radiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, People's Republic of China.
Background: COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying sleep problems (SP) post-COVID-19 are unclear.
Purpose: This study investigated SP-related brain functional connectivity (FC) alterations.
Quant Imaging Med Surg
January 2025
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background: There are currently no deep learning models applying resting-state functional magnetic resonance imaging (rs-fMRI) data to distinguish patients with Parkinson's disease (PD) and healthy controls (HCs). Moreover, no study has correlated objective gait parameters with brain network alterations in patients with PD. We propose BrainNetCNN + CL, applying a convolutional neural network (CNN) and joint contrastive learning (CL) method to brain network analysis to classify patients with PD and HCs, and compare their performance with classical classification methods.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Rapid eye movement sleep behavior disorder (RBD) is associated with pathological α-synuclein deposition and may have different damage directions due to α-synuclein spreading orientations. Recent functional imaging studies of Parkinson's disease (PD) with RBD have identified abnormalities in connectivity, but effective connectivity (EC) for this altered orientation is understudied. Here, we aimed to explore altered intrinsic functional connectivity (FC) and EC in PD patients with probable RBD (pRBD).
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Background: Approximately half of human immunodeficiency virus (HIV) patients experience HIV-associated neurocognitive disorders (HAND); however, the neurophysiological mechanisms underlying HAND remain unclear. This study aimed to evaluate changes in functional brain activity patterns during the early stages of HIV infection by comparing local and global indicators using resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: A total of 165 people living with HIV (PLWH) but without neurocognitive disorders (PWND), 173 patients with asymptomatic neurocognitive impairment (ANI), and 100 matched healthy controls (HCs) were included in the study.
Front Neurosci
January 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Capital Medical University, Beijing, China.
Purpose: To investigate the changes in cerebral hemispheric functional connections in patients with acute acquired concomitant esotropia (AACE) and their relationship with clinical manifestations, utilizing voxel-mirrored homotopic connectivity (VMHC).
Methods: A prospective, observational study was conducted involving 32 AACE patients and 31 age-, sex-, and education-matched healthy controls (HC). The resting-state functional magnetic resonance imaging (rs-fMRI) signals, binocular vision function, and psychometric scale scores were collected rs-fMRI data and structural image data were analyzed for VMHC, and a two-sample -test was used to analyze the differences in VMHC between groups.
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