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Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.
Brain Sci
June 2024
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDFBridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium.
bioRxiv
April 2023
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, 84132.
Article Synopsis
- Researchers in neuroscience are using Big Data to improve the reliability and replication of cognitive studies, focusing on memory testing.
- They conducted a mega-analysis with data from 53 studies, involving over 10,500 individuals, employing methods to harmonize data and reduce variability across different sites.
- Their findings show that large-scale data sharing can enhance the reproducibility of research in behavioral sciences, and they offer a free conversion tool for this purpose.
Altered lateralization of the cingulum in deployment-related traumatic brain injury: An ENIGMA military-relevant brain injury study.
Hum Brain Mapp
April 2023
Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Traumatic brain injury (TBI) in military populations can cause disruptions in brain structure and function, along with cognitive and psychological dysfunction. Diffusion magnetic resonance imaging (dMRI) can detect alterations in white matter (WM) microstructure, but few studies have examined brain asymmetry. Examining asymmetry in large samples may increase sensitivity to detect heterogeneous areas of WM alteration in mild TBI.
View Article and Find Full Text PDFClinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.
JAMA Neurol
January 2016
Department of Neuroscience, University of California, San Diego, La Jolla.
Importance: Identifying measures that are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis of Huntington disease (HD) has implications for designing clinical trials.
Objective: To identify the earliest features associated with the motor diagnosis of HD in the Prospective Huntington at Risk Observational Study (PHAROS).
Design, Setting, And Participants: A prospective, multicenter, longitudinal cohort study was conducted at 43 US and Canadian Huntington Study Group research sites from July 9, 1999, through December 17, 2009.
Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial.
Psychosom Med
September 2016
From the Weight Control and Diabetes Research Center (McCaffery, Wing), The Miriam Hospital and Warren Alpert School of Medicine at Brown University, Providence, Rhode Island; Center for Statistical Sciences (Papandonatos, Erar), Brown University, Providence, Rhode Island; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania (Faulconbridge, Wadden), Philadelphia, Pennsylvania; Department of Genetics & Genomic Sciences (Peter), Mount Sinai School of Medicine, New York, New York; Look AHEAD Coordinating Center, Division of Public Health Sciences (Wagenknecht, Anderson), Wake Forest School of Medicine, Winston-Salem, North Carolina; and Department of Biostatistical Sciences (Pajewski), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Objectives: Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with Type 2 diabetes or change in depressive symptoms during behavioral weight loss.
Methods: The Illumina CARe iSelect (IBC) chip and Cardiometabochip were characterized in 2118 overweight or obese participants with Type 2 diabetes from Look AHEAD (Action for Health in Diabetes), a randomized trial to determine the effects of intensive life-style intervention and diabetes support and education on cardiovascular morbidity and mortality.
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