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Working memory during spontaneous migraine attacks: an fMRI study. | LitMetric

AI Article Synopsis

  • The study aimed to explore how working memory is affected during a migraine attack using fMRI technology.
  • Cognitive issues are frequent during migraine episodes, yet the underlying neural mechanisms were unclear.
  • Results showed reduced cognitive performance during migraines, with increased activation in specific brain areas associated with working memory, indicating that migraine patients compensate for cognitive challenges by engaging certain brain regions more actively.

Article Abstract

Objective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI).

Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown.

Methods: In a fMRI within-subject test-retest design study, eleven women (32 years of age, average) with episodic migraine were evaluated twice, first during a spontaneous migraine attack, and again in a pain-free period. Each session consisted in a cognitive assessment and fMRI while performing a working memory task (N-back).

Results: Cognitive test scores were lower during the ictal session than in the pain-free session. Regions typically associated with working memory were activated during the N-back task in both sessions. A voxel wise between session comparison showed significantly greater activation in the left frontal pole and orbitofrontal cortex during the attack relative to the interictal phase.

Conclusion: Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10858146PMC
http://dx.doi.org/10.1007/s10072-023-07120-0DOI Listing

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