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A pilot randomized, placebo-controlled, double-blind study of omega-3 fatty acids to prevent paclitaxel-associated acute pain syndrome in breast cancer patients: Alliance A22_Pilot2. | LitMetric

AI Article Synopsis

  • Paclitaxel treatment is linked to acute pain syndrome (P-APS) and chronic peripheral neuropathy (CIPN), with a pilot study exploring if omega-3 fatty acids can reduce these conditions.
  • Patients receiving weekly paclitaxel for breast cancer were either given omega-3 supplements or placebo, and their pain levels were tracked throughout the treatment.
  • Results showed no significant difference in the incidence of P-APS or CIPN between the omega-3 and placebo groups, suggesting that omega-3 fatty acids may not be effective for preventing these pain-related issues.

Article Abstract

Purpose: Paclitaxel is associated with an acute pain syndrome (P-APS- and chronic chemotherapy-induced peripheral neuropathy (CIPN). P-APS is associated with higher risk of CIPN. Omega-3 fatty acids have well-established anti-inflammatory and neuroprotective properties. The primary purpose of this pilot study was to assess whether omega-3 fatty acids could decrease P-APS and thus CIPN.

Methods: Patients scheduled to receive weekly paclitaxel for breast cancer were randomized to receive 4 g of omega-3 acid ethyl esters (Lovaza) or placebo, beginning 1 week prior and continued until paclitaxel was stopped. Patients completed acute pain questionnaires at baseline, daily after each treatment, and 1 month after completion of therapy.

Results: Sixty patients (49 evaluable) were randomized to treatment versus placebo. Seventeen (68.0%) patients receiving the omega-3 fatty acids intervention experienced P-APS, compared to 15 (62.5%) of those receiving placebo during the first week of treatment (p = 0.77). Over the full 12-week study, 21 (84.0%) patients receiving the omega-3 fatty acid intervention experienced P-APS, compared to 21 (87.5%) of those receiving placebo (p = 1.0). Secondary outcomes suggested that those in the intervention arm used more over-the-counter analgesics (OR: 1.65, 95% CI: 0.72-3.78, p = 0.23), used more opiates (OR: 2.06, 95% CI: 0.55-7.75, p = 0.28), and experienced higher levels of CIPN (12.8, 95% CI: 7.6-19.4 vs. 8.4, 95% CI: 4.6-13.2, p = 0.21).

Conclusions: The results of this pilot study do not support further study of the use of omega-3 fatty acids for the prevention of the P-APS and CIPN.

Trial Registration: Number: NCT01821833.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642207PMC
http://dx.doi.org/10.1007/s00520-023-08082-xDOI Listing

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