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Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.
Europace
December 2024
Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands.
In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize for his discovery of the mechanism of the electrocardiogram (ECG). Building on Einthoven's legacy, electrocardiography allows the monitoring of cardiac bioelectricity through solutions to the so-called forward and inverse problems. These solutions link local cardiac electrical signals with the morphology of the ECG, offering a reversible connection between the heart's electrical activity and its representation on the body surface.
View Article and Find Full Text PDFIt's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine.
Dis Model Mech
November 2024
Biology Department, Muhlenberg College, Allentown, PA 18104, USA.
The 2024 Nobel Prize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation". The award celebrates the discovery of small regulatory miRNAs and their mRNA targets, published over three decades ago. The groundwork for this discovery was laid during the early 1980s, when Ambros began studying mutations that caused heterochronic defects in the nematode Caenorhabditis elegans - or shifts in the temporal identities of cells.
View Article and Find Full Text PDFAnwar Fazal-A Breastfeeding Advocate Extraordinaire.
J Hum Lact
November 2024
Beruffsverband vun den Laktatiounsberoderinnen zu Letzebuerg, Luxembourg.
Anwar Fazal has been a driving force in the founding of several civil society organizations in the areas of health, human rights, environment, and peace, that have been at the forefront of activism locally, nationally, and globally. In this interview, he shares his journey of 6 decades, involving a multiverse of public interest issues, which led him into the breastfeeding movement. It began with the setting up of the International Baby Food Action Network (IBFAN), a pioneering action that triggered the formation of Health Action International (HAI), Pesticide Action Network (PAN), and the World Alliance for Breastfeeding Action (WABA).
View Article and Find Full Text PDF30 years of Journal of Synchrotron Radiation and synchrotron science.
J Synchrotron Radiat
January 2025
Molecular Biophysics Group, Life Sciences Building, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom.
Journal of Synchrotron Radiation (JSR) came into being with the publication of its inaugural issue in October 1994 that contained 15 full articles comprising 100 pages. Thirty years of JSR has coincided with several Nobel Prizes that have arisen from the work undertaken on synchrotron radiation sources, with the first of these awarded to Sir John Walker in 1997, just three years after the launch of JSR, and celebrated on the front cover of the journal's July 1999 issue. This article provides an insight into the motivation as well as the journey of establishing this important journal for the IUCr and the synchrotron radiation community which has continued to grow.
View Article and Find Full Text PDFThe 75-Year Anniversary of the Department of Physiology and Pharmacology at Karolinska Institutet-Examples of Recent Accomplishments and Future Perspectives.
Pharmacol Rev
October 2024
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)
Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking.
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