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A framework for the simulation of individual glycan coordinates to analyze spatial relationships within the glycocalyx.
Front Cell Dev Biol
January 2025
Department of Physics, Faculty of Sciences, FAU Erlangen-Nuremberg, Erlangen, Germany.
The glycocalyx is a dense and dynamic layer of glycosylated species that covers every cell in the human body. It plays crucial roles in various cellular processes in health and disease, such as cancer immune evasion, cancer immune therapy, blastocyst implantation, and functional attenuation of membrane protein diffusion. In addition, alterations in glycocalyx structure may play an important role in ocular surface diseases, e.
View Article and Find Full Text PDFNovel Intragenic and Genomic Variants Highlight the Phenotypic Variability in -Related Disease.
Genes (Basel)
December 2024
Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
: Disruption of results in microphthalmia with linear skin lesions (MLS) characterized by microphthalmia/anophthalmia, corneal opacity, aplastic skin lesions, variable central nervous system and cardiac anomalies, intellectual disability, and poor growth in heterozygous females. Structural variants consisting of chromosomal rearrangements or deletions are the most common variant type, but a small number of intragenic variants have been reported. : Exome sequencing identified variants affecting .
View Article and Find Full Text PDFAssociation of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer.
Postepy Dermatol Alergol
October 2024
Martin's Biopsy Center, Ltd., Martin, Slovakia.
Article Synopsis
- The study aimed to assess the link between Bcl-2 protein, Ki-67 antigen expression, and the apoptotic index in relation to the behavior of non-melanoma eyelid tumors, particularly focusing on their aggressiveness.
- A total of 68 patients with 70 confirmed non-melanoma eyelid tumors were analyzed, with basal cell carcinoma being the most common type and a significant correlation found between tumor size and aggressiveness.
- The findings suggest that understanding these biomarkers can help in tailoring effective treatments to improve aesthetic results and survival rates for patients with these tumours.
Monkeys engage in visual simulation to solve complex problems.
Curr Biol
December 2024
Department of Neuroscience, Brown University, Meeting Street, Providence, RI 02906, USA; Robert J. and Nancy D. Carney Institute for Brain Sciences, Brown University, Angell Street, Providence, RI 02906, USA. Electronic address:
Visual simulation-i.e., using internal reconstructions of the world to experience potential future versions of events that are not currently happening-is among the most sophisticated capacities of the human mind.
View Article and Find Full Text PDFCongenital anterior segment ocular disorders: Genotype-phenotype correlations and emerging novel mechanisms.
Prog Retin Eye Res
September 2024
Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA; Department of Pediatrics and Children's Research Institute, Medical College of Wisconsin and Children's Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. Electronic address:
Development of the anterior segment of the eye requires reciprocal sequential interactions between the arising tissues, facilitated by numerous genetic factors. Disruption of any of these processes results in congenital anomalies in the affected tissue(s) leading to anterior segment disorders (ASD) including aniridia, Axenfeld-Rieger anomaly, congenital corneal opacities (Peters anomaly, cornea plana, congenital primary aphakia), and primary congenital glaucoma. Current understanding of the genetic factors involved in ASD remains incomplete, with approximately 50% overall receiving a genetic diagnosis.
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