AI Article Synopsis
- The study examines distant metastatic penile cancer (DMPC), focusing on its clinical features and prognostic factors.
- The analysis includes 108 DMPC cases from 2004 to 2019, revealing a median cancer-specific survival (CSS) of 9 months, with significant variation based on patient characteristics, particularly race.
- No significant survival difference was found between treatment groups, suggesting an overall poor prognosis and limited effective treatment options for DMPC.
Article Abstract
Objective: To investigate the clinical features of distant metastatic penile cancer (DMPC) and the factors influencing its prognosis.
Methods: We searched the Surveillance, Epidemiology and End Results Database for cases of DMPC diagnosed between 2004 and 2019, analyzed their clinical characteristics and the cancer-specific survival (CSS) rates relating to different factors using the Kaplan-Meier method and the differences among the variables by log-rank test. We determined the variables independently associated with CSS by Cox regression analysis.
Results: According to the inclusion criteria, 108 cases of DMPC were identified. The patients were mainly married White people, with a median CSS of 9 months, and 1-, 2- and 3-year CSS rates of 36.4%, 17.8% and 13.5%, respectively. Pairwise comparison showed no statistically significant differences in the median overall CSS among the patients in the surgery, chemotherapy and surgery + chemotherapy groups (8 mo vs 9 mo vs 13 mo, P > 0.05). Race was an independent factor affecting the prognosis of CSS.
Conclusion: Distant metastatic penile cancer is a rare malignancy with poor prognosis, for which there have been no existing ideal treatment options.
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