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The significance of endogenous immune surveillance in acute lymphoblastic leukemia (ALL) remains controversial. Using clinical B-ALL samples and a novel mouse model, we show that neoantigen-specific CD4+ T cells are induced to adopt type-1 regulatory (Tr1) function in the leukemia microenvironment. Tr1s then inhibit cytotoxic CD8+ T cells, preventing effective leukemia clearance.
View Article and Find Full Text PDFEvaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis).
BMC Vet Res
January 2025
Department of Veterinary Sciences, Veterinary Teaching Hospital "Mario Modenato", University of Pisa, via Livornese snc, San Piero a Grado, Pisa, Italy.
Background: Current endogenous indicators utilised in avian medicine are not sensitive enough to detect renal disease in its early stages. Alternative markers ought to be examined as a result. The aim is to investigate the accuracy of limited-sampling models for glomerular filtration rate (GFR) in adult seagulls using plasma clearance of iohexol (IOX).
View Article and Find Full Text PDFTunnel wash water in a cold climate: characteristics, ecotoxicological risk, and effect of sedimentation.
Environ Sci Pollut Res Int
January 2025
Department of Civil and Environmental Engineering, Norwegian University of Science and Technology, S. P. Andersens Veg 5, 7031, Trondheim, Norway.
The characterization of tunnel wash water (TWW) from 12 Norwegian tunnels showed very high concentrations of total suspended solids (TSS), metals, and polycyclic aromatic hydrocarbons (PAHs). Iron (Fe), aluminum (Al), and manganese (Mn) were mainly particle-associated. They are efficiently removed by sedimentation, while the dissolved concentrations of toxic metals like Cu, Zn, and As did not change.
View Article and Find Full Text PDFPrimary Human Macrophage and Tenocyte Tendon Healing Phenotypes Changed by Exosomes Per Cell Origin.
Tissue Eng Part A
January 2025
Orthopaedic and Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, USA.
The high failure rate of surgical repair for tendinopathies has spurred interest in adjunct therapies, including exosomes (EVs). Mesenchymal stromal cell (MSC)-derived EVs (MSCdEVs) have been of particular interest as they improve several metrics of tendon healing in animal models. However, research has shown that EVs derived from tissue-native cells, such as tenocytes, are functionally distinct and may better direct tendon healing.
View Article and Find Full Text PDFAdvancements in synthesis, immobilization, characterization, and multifaceted applications of silver nanoparticles: A comprehensive review.
Heliyon
December 2024
Department of Dyes and Chemical Engineering, Bangladesh University of Textiles, Dhaka, 1208, Bangladesh.
Silver nanoparticles (AgNPs) have attracted significant interest in recent years owing to their unique physicochemical properties, including antimicrobial reduction capabilities, photocatalytic activity, self-cleaning features, superhydrophobicity, and electrical conductivity. Their characteristics render them highly advantageous for various textile, electronics, food and agriculture, water treatment, and biomedical applications. This detailed analysis explores the recent benefits and drawbacks of various synthesis methods, immobilization techniques, and characterization of AgNPs while emphasizing novel strategies that improve their functionality across different substrates.
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