AI Article Synopsis
- The study aimed to analyze the pharmacogenetic profiles of Brazilian psychiatric patients based on their ethnic backgrounds.
- It utilized the GnTech database and assessed data from 359 patients, focusing on 26 key pharmacogenes that influence responses to psychotropic drugs.
- The findings indicated significant differences in pharmacogene variant frequencies across different ethnic groups, highlighting the importance of personalized medicine in drug treatment decisions, particularly in Brazil's diverse population.
Article Abstract
This work was designed to identify the pharmacogenetic profile of Brazilian psychiatric patients receiving psychoactive drug treatment according to ethnicity. Based on the GnTech database, this cross-sectional study analyzed data from self-reported sociodemographic and genetic results from the next-generation sequencing panel composed of 26 pharmacogenes from 359 psychotropic drug users. Variant frequencies of multiple pharmacogenes presented differences between ethnicities (, , , , , , , , , , , , , , , , , and ), endorsing the necessity of individual-level analyses in drug treatment. A discussion of pharmacogenomic test implementation in psychiatric clinical practice is needed to improve treatment choices, especially in Brazil, a multiethnic country.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/pgs-2023-0075 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!