Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41587-023-01991-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
John Brooksby was an outstanding Scottish veterinary virologist who worked at the Pirbright Institute (Pirbright) for 40 years, including 16 as the institute's director. He devised quantitative methods for measuring neutralising antibodies and perfected a complement fixation test for the diagnosis, typing and strain differentiation of foot and mouth disease (FMD), especially when combined with neutralisation. He identified four of the seven types of FMD virus (FMDV) and many subtypes.
View Article and Find Full Text PDFEuDockScore: Euclidean graph neural networks for scoring protein-protein interfaces.
Bioinformatics
November 2024
Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada.
Motivation: Protein-protein interactions are essential for a variety of biological phenomena including mediating biochemical reactions, cell signaling, and the immune response. Proteins seek to form interfaces which reduce overall system energy. Although determination of single polypeptide chain protein structures has been revolutionized by deep learning techniques, complex prediction has still not been perfected.
View Article and Find Full Text PDFPotential vs Challenges of Expanding the Protein Universe With Genetic Code Expansion in Eukaryotic Cells.
J Mol Biol
November 2024
Biocenter, Johannes Gutenberg University Mainz, 55128, Mainz, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany. Electronic address:
Following decades of innovation and perfecting, genetic code expansion has become a powerful tool for in vivo protein modification. Some of the major hurdles that had to be overcome include suboptimal performance of GCE-specific translational components in host systems, competing cellular processes, unspecific modification of the host proteome and limited availability of codons for reassignment. Although strategies have been developed to overcome these challenges, there is critical need for further advances.
View Article and Find Full Text PDFAnlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials.
J Leukoc Biol
September 2024
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhu Xi Road, Hexi District, Tianjin, 300060, China.
Murine cytokine-induced killer (CIK) cells are heterologous cells that kill various allogeneic and isogenic tumors and have functional and phenotypic characteristics of natural killer cells and T lymphocytes. However, the effect of CIK cells alone on solid tumor therapy is only limited. To enhance the therapeutic effect, it is vital to discover a mix of several therapy approaches.
View Article and Find Full Text PDFFirst-line immunotherapy in non-small cell lung cancer: how to select and where to go.
Expert Rev Respir Med
December 2023
Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Article Synopsis
- Immunotherapy (IO), particularly immune checkpoint inhibitors (ICIs), has transformed lung cancer treatment, especially for metastatic nonsmall cell lung cancer (NSCLC), but only a subset of patients respond well to these therapies.
- The review examines the use of ICIs in first-line treatment for metastatic NSCLC, focusing on various predictive factors, including biomarkers and mechanisms of resistance, to improve patient selection.
- Ongoing trials are exploring new combinations of immune therapies to enhance effectiveness, highlighting the critical need to identify patients who are most likely to benefit from treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!