Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41590-023-01657-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eomes expression identifies the early bone marrow precursor to classical NK cells.
Nat Immunol
July 2024
Committee on Immunology, University of Chicago, Chicago, IL, USA.
Natural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-focused responses to intracellular pathogens and tumors. Type 1 innate lymphoid cells (ILC1s) also produce type 1 cytokines but reside in tissues and are not cytotoxic. Whether these differences reflect discrete lineages or distinct states of a common cell type is not understood.
View Article and Find Full Text PDFBiochemical and biophysical characterization of natural polyreactivity in antibodies.
Cell Rep
October 2023
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address:
To become specialized binders, antibodies undergo a process called affinity maturation to maximize their binding affinity. Despite this process, some antibodies retain low-affinity binding to diverse epitopes in a phenomenon called polyreactivity. Here we seek to understand the molecular basis of this polyreactivity in antibodies.
View Article and Find Full Text PDFGATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
Immunity
January 2023
Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Department of Pediatrics, University of Chicago, Chicago, IL, USA. Electronic address:
There is growing recognition that regionalization of bacterial colonization and immunity along the intestinal tract has an important role in health and disease. Yet, the mechanisms underlying intestinal regionalization and its dysregulation in disease are not well understood. This study found that regional epithelial expression of the transcription factor GATA4 controls bacterial colonization and inflammatory tissue immunity in the proximal small intestine by regulating retinol metabolism and luminal IgA.
View Article and Find Full Text PDFSynthesis of the pentasaccharide repeating unit from and measurement of its inflammatory properties.
RSC Adv
April 2021
Department of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA
The roles played by the gut microbiome in human health are increasingly recognized, and the prevalence of specific microorganisms has been correlated with different diseases. For example, blooms of the Gram-positive bacterium have been correlated with inflammatory bowel disease, and recently a polysaccharide produced by this organism was shown to stimulate release of inflammatory cytokines. This stimulation was proposed to signal through toll-like receptor 4 (TLR4).
View Article and Find Full Text PDFThe molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Proc Natl Acad Sci U S A
September 2021
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637;
Microorganisms have coevolved diverse mechanisms to impair host defenses. A major one, superantigens, can result in devastating effects on the immune system. While all known superantigens induce vast immune cell proliferation and come from opportunistic pathogens, recently, proteins with similar broad specificity to antibody variable (V) domain families were identified in a commensal microbiota.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!