An efficient thermal-structural numerical solver for Additive Manufacturing has been developed based on a modified Lagrangian approach to solve the energy conservation equations in differential form. The heat transfer is modeled using the finite difference method applied to a deforming Lagrangian mesh. The structural solver has been enhanced with the proposed effective quasi-elastic differential approach for modeling the elastoplastic behavior of materials. The algorithm is relatively simple to implement yet is highly effective. The solver can predict shape deformations of metal parts printed using the laser powder bed fusion technique. The second key capability of the solver is the auto-compensation of distortions of 3D-printed parts by proposing a corrected geometry of a surface to be printed, in order to ensure minimal deviation of the actual printed part from the desired one, even under non-optimal operating conditions or for complex shapes. All the simulation results have been verified in real-life experiments for 3D parts of sizes ranging from 10 to 15 mm up to 40 mm.
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http://dx.doi.org/10.1038/s41598-023-43968-0 | DOI Listing |
BMC Complement Med Ther
January 2025
Laser Research Centre, Faculty of Health Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg, 2028, South Africa.
Background: Amongst all neoplastic diseases, breast cancer represents a major cause of death among the female population in developed and developing countries. Since alkaloid drugs are commonly used in chemotherapy to manage this disease, this study investigated the anti-proliferative effectiveness of alkaloid-rich fractions of Senna didymobotrya leaves only and with laser irradiation against MCF-7 breast cancer cells.
Method And Materials: A powdered sample of the plant leaves was extracted with 50% ethanol, filtered and their pH was adjusted with acid and base solution followed by partitioning with chloroform and ethyl acetate solvents.
Nat Commun
January 2025
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Optimizing process and heat-treatment parameters of laser powder bed fusion for producing Ti-6Al-4V alloys with high strength and ductility is crucial to meet performance demands in various applications. Nevertheless, inherent trade-offs between strength and ductility render traditional trial-and-error methods inefficient. Herein, we present Pareto active learning framework with targeted experimental validation to efficiently explore vast parameter space of 296 candidates, pinpointing optimal parameters to augment both strength and ductility.
View Article and Find Full Text PDFJ Food Sci
January 2025
College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, China.
Infant formulas are constantly being updated and upgraded, and N-glycans are functional glycans that have not been fully exploited to date. Commercial whey protein materials are often used as basic ingredients in infant formulas. Therefore, it is important to study N-glycans in commercial whey protein materials.
View Article and Find Full Text PDFAnal Methods
January 2025
National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing, Beijing, 100029, China.
With the increasing demand for energy, nuclear energy has been developing rapidly. The quantitative detection and qualitative identification of uranium (U) are of great significance for the comprehensive and efficient use of U resources and the control of nuclear and radioactive substances. In this study, the detection of U is divided into liquid sample detection, solid sample detection, gas sample detection, and industrial detection from the perspectives of the sample state and detection environment.
View Article and Find Full Text PDFBiomater Adv
January 2025
School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, United Kingdom. Electronic address:
Laser-powder bed fusion (PBF-LB) has enabled production of customised skeletal implants that incorporate porous lattices structures to enable bone ingrowth. However, the inherent surface roughness of PBF-LB, characterised by partially adhered particles and undulating sub-topography, remains a barrier to adoption. As such PBF-LB surfaces require several time-consuming post-processing steps, nevertheless, conventional finishing techniques are often limited by geometrical part complexity, making them unsuitable for porous PBF-LB parts.
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