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Marine pollutant Phenanthrene (PHE) exposure causes immunosuppression of hemocytes in crustacean species, Scylla paramamosain. | LitMetric

Marine pollutant Phenanthrene (PHE) exposure causes immunosuppression of hemocytes in crustacean species, Scylla paramamosain.

Comp Biochem Physiol C Toxicol Pharmacol

Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang Agriculture and Forestry University, Hangzhou 311300, China. Electronic address:

Published: January 2024

AI Article Synopsis

  • Phenanthrene (PHE), a toxic polycyclic aromatic hydrocarbon (PAH), is prevalent in aquatic settings and adversely affects marine life, particularly crustaceans like the Scylla paramamosain.
  • In an experiment, varying concentrations of PHE (0, 0.7, 7, 70 μg/L) were administered to groups of 35 crabs, revealing changes in hemocyte characteristics and increased total hemocyte counts as PHE levels rose.
  • The results indicated that PHE exposure caused hepatopancreas damage and altered antioxidant enzyme activities, while also significantly up-regulating key immune-related genes, underscoring the potential dangers of PAH pollution on marine ecosystems.

Article Abstract

Phenanthrene (PHE), a representative polycyclic aromatic hydrocarbons (PAHs), is widely found in aquatic environments, which exhibits high toxicity to aquatic organisms and has a substantial impact on overall health. In order to investigate the immunosuppressive effects of PHE exposure on marine crustacean species, the Scylla paramamosain was exposure to different concentrations of PHE, which was 0 μg/L (control group), 0.7 μg/L, 7 μg/L, or 70 μg/L PHE with 35 individuals in every group, respectively. The results showed that the color of hemocytes gradually deepened with increasing PHE concentration, and the total hemocyte count (THC) was activated and increased after PHE exposure analyzed by Flow cytometry. Meanwhile, compared with the control group, cryostat sections of hepatopancreas showed cell infiltration, cell steatosis, eosinophilic masses and vacuolization in PHE groups. The superoxide dismutase (SOD) activity was decreased immensely in PHE exposure groups, meanwhile, the acid phosphatase (ACP) activity and glutathione (GSH) activities were increased after PHE exposure compared with control group. Moreover, the expression profile of Crustin, TLR, MCM7, JAK, caspase, Moyosin and P53 were up-regulated significantly after 7th day PHE exposure in all treatment groups by Q-PCR. Those data illustrated that PHE exposure could inhibit the immune function of mud crab by causing hepatopancreas damage, induce the activity of antioxidant enzymes and the expression of immune genes. These data provide a scientific basis for evaluating the impact of PAH pollution on marine organisms.

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Source
http://dx.doi.org/10.1016/j.cbpc.2023.109761DOI Listing

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