A reusable electrochemical glassy carbon electrode (GCE) platform based on the acid-responsive host-guest interaction between β-cyclodextrin (β-CD) and benzimidazole (BM) derivatives was developed. The β-CD can specifically recognize the BM derivative through the acid -responsive host-guest interaction. The electrode was first modified by eletrografting to immobilize a diamine linker (Boc-EDA), resulting in GCE in which one amine was used for covalent immobilization to the electrode and another Boc protected amine was used to solid-phase synthesis on following step-by-step modifications on the electrode. After deprotection of the Boc group on the GCE, carbonyldiimidazole (CDI)-activated β-CD was coupled with -NH on the electrode to result in GCE. Due to the nonspecific interaction, we further improved the GCE electrode by introducing immobilized poly(ethylene glycol) methyl ether (PEG-Me) to result in GCE, along with optimized procedures. CV, DPV, and EIS methods were applied for recording the electrochemistry signals. We utilized GCE to investigate the host-guest interaction and found the electrochemical signal exhibited dynamic behavior. The GCE was able to regenerate the β-CD surface more than 20 times after HCl acidic washes. We further investigated the interaction of carbendazim (CBZ), a commonly used fungicide in the agriculture and food industry, and observed a positive electrochemical response. The sensor design has potential applications in ensuring food safety.
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