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Future Prospects and Regulatory Pathways for Invasome Technologies in Transdermal Drug Delivery.
Assay Drug Dev Technol
January 2025
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
Exploration of synergistically engineered invasomes of fluconazole incorporated with safranal against onychomycosis for enhanced transungual delivery.
Drug Dev Ind Pharm
December 2024
Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard University, New Delhi, India.
Objective: The preparation of safranal-containing invasomes for fluconazole (FLU-IN) is investigated in the current research work to augment FLU permeation, bioavailability, and solubility nail for transungual delivery.
Methods: FLU-IN was prepared utilizing the 'thin-film hydration process', and for optimization, 'Box-Behnken design (BBD)' was employed. Entrapment efficiency (EE), Poly-dispersity index (PDI), FLU release, vesicle size and zeta potential were used to characterize FLU-INopt.
The ultrastructural identity of some cells in Sphaerolaimus gracilis de Man, 1876.
Tissue Cell
December 2024
University of Eastern Finland (UEF), Department of Environmental and Biological Sciences, Yliopistokatu 7, Joensuu FI-80101, Finland. Electronic address:
The fine structure of fibroblasts, lymphocytes, neurosecretory cells, stem cells, and steroidogenic cells in the nematode Sphaerolaimus gracilis was studied by transmission electron microscopy. Fibroblasts, lymphocytes, and stem cells were found in the lateral position at the level of the renette pore (ventral pore). Fibroblasts were characterized by long cellular processes.
View Article and Find Full Text PDFExosome-mediated Advancements in Plastic Surgery: Navigating Therapeutic Potential in Skin Rejuvenation and Wound Healing.
Plast Reconstr Surg Glob Open
August 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.
Article Synopsis
- Exosomes, small vesicles from various stem cells, show great promise in wound healing by improving cell communication and inflammation management.
- They help with collagen production and scar reduction, with clinical cases supporting their effectiveness in treating wounds and minimizing hypertrophic scars.
- The study includes five case reports on exosome therapy in plastic surgery, highlighting their positive impact on healing and scarring, which suggests a need for more extensive research in this area.
Tracking Small Extracellular Vesicles Using a Minimally Invasive PicoGreen Labeling Strategy.
ACS Appl Bio Mater
November 2024
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, United States.
Extracellular vesicles (EVs) are cell-secreted lipid bilayer delimited particles that mediate cellular communication. These tiny sacs of cellular information play an important role in cell communication and alter the physiological process under both normal and pathological conditions. As such, tracking EVs can provide valuable information regarding the basic understanding of cell communication, the onset of early malignancy, and biomarker discovery.
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