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Breaking Down the AAP Guideline on Childhood Obesity.
Am Fam Physician
October 2023
Lancaster General Hospital Family Medicine Residency, Lancaster, Pennsylvania.
Self-deposited ultrasmall Ru nanoparticles on carbon nitride with high peroxidase-mimicking activity for the colorimetric detection of alkaline phosphatase.
J Colloid Interface Sci
February 2023
School of Materials Science and Engineering, University of Jinan, Jinan 250022, China. Electronic address:
Carbon nitride (CN) nanosheets are known as peroxidase mimics, but the low activity hinders their further application. Embedding active metal nanoparticles onto the CN nanosheets is expected to break this limitation. Herein, highly dispersed ultrasmall Ru nanoparticles are anchored onto the CN through spontaneous redox reaction.
View Article and Find Full Text PDFEvaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder.
NPJ Digit Med
May 2022
CHOC Children's, Orange, CA, USA.
Autism spectrum disorder (ASD) can be reliably diagnosed at 18 months, yet significant diagnostic delays persist in the United States. This double-blinded, multi-site, prospective, active comparator cohort study tested the accuracy of an artificial intelligence-based Software as a Medical Device designed to aid primary care healthcare providers (HCPs) in diagnosing ASD. The Device combines behavioral features from three distinct inputs (a caregiver questionnaire, analysis of two short home videos, and an HCP questionnaire) in a gradient boosted decision tree machine learning algorithm to produce either an ASD positive, ASD negative, or indeterminate output.
View Article and Find Full Text PDFComparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
J Food Biochem
May 2022
College of Life Sciences, China Jiliang University, Hangzhou, China.
To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase. Their chemical features were determined using high-performance liquid chromatography and infrared spectroscopy. The antioxidant properties were performed both in vitro and in vivo.
View Article and Find Full Text PDFOptimized Doxorubicin Chemotherapy for Diffuse Large B-cell Lymphoma Exploits Nanocarrier Delivery to Transferrin Receptors.
Cancer Res
February 2021
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
New treatments are needed to address persistent unmet clinical needs for diffuse large B-cell lymphoma (DLBCL). Overexpression of transferrin receptor 1 (TFR1) is common across cancer and permits cell-surface targeting of specific therapies in preclinical and clinical studies of various solid tumors. Here, we developed novel nanocarrier delivery of chemotherapy via TFR1-mediated endocytosis, assessing this target for the first time in DLBCL.
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