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| http://dx.doi.org/10.1128/mbio.01693-23 | DOI Listing |
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Proteomic profiling of neonatal herpes simplex virus infection on dried blood spots.
Commun Med (Lond)
December 2024
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Background: Neonatal herpes simplex virus (HSV) infection is life-threatening, with a mortality of up to 70-80% when disseminated, often due to vague symptoms and delayed treatment. Neonatal screening using dried blood spot (DBS) samples is among the most impactful preventative health measures ever implemented, but screening for HSV has not been investigated.
Methods: We investigated high throughput multiplexed proteomics on DBS samples collected on days 2-3 of life from a nationwide cohort of neonates with HSV infection (n = 53) and matched controls.
Rash Decisions: Improving Pediatrician Skills in Dermatologic Diagnosis.
J Pediatr
December 2024
Division of Pediatric Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and University of Toronto; Toronto, Canada. Electronic address:
Objectives: To examine pediatrician diagnostic skill development of dermatology image-based cases via a web-based tool and to determine case-level variables that were associated with diagnostic error.
Study Design: This was a multi-center, prospective, cross-sectional study. A convenience sample of pediatric trainees and attendings were eligible for participation.
Correction: Development and characterization of formulations based on combinatorial potential of antivirals against genital herpes.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
SCES's Indira College of Pharmacy, New Mumbai Pune Highway, Tathawade, Pune, India.
Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander?
Case Rep Ophthalmol
November 2024
Department of Ophthalmology, University of Florida, Gainesville, FL, USA.
Introduction: Phlyctenular keratoconjunctivitis is an inflammatory condition arising from a type IV hypersensitivity reaction, presenting with inflamed nodules on the conjunctiva and cornea. Scleritis is a severe ocular inflammation linked to systemic diseases, potentially vision threatening, and involving immune responses similar to phlyctenular keratoconjunctivitis. This case report discusses a patient with a history of herpes simplex virus (HSV)-2 infection who primarily developed phlyctenular conjunctivitis and later progressed to nodular scleritis.
View Article and Find Full Text PDFBilateral Chronic Herpetic Anterior Uveitis in an Immunocompetent Patient.
Int Med Case Rep J
November 2024
Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Purpose: To present a case of bilateral herpes simplex anterior uveitis in an immunocompetent patient.
Methods: Case Report.
Results: A 42-year-old Kenyan female presented with a 2-year history of intermittent painful eye redness associated with blurring of vision of both eyes.
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