AI Article Synopsis
- The white-spotted flower chafer extract (PBE) is traditionally used for liver issues and this study examines its effects on platelet aggregation.
- PBE was found to inhibit the activation of integrin αIIb/β by influencing cyclic nucleotides, which are vital for platelet function.
- The extract also impacted several signaling molecules in platelets, demonstrating strong antiplatelet effects that may help in preventing cardiovascular diseases related to thrombosis.
Article Abstract
The white-spotted flower chafer, , is used as a traditional remedy against liver cirrhosis, hepatitis, and hepatic cancer. In this study, we investigated if extract (PBE) inhibited platelet aggregation via integrin αIIb/β regulation. We observed that PBE inhibited αIIb/β activation by regulating the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate. Additionally, PBE affected phosphatidylinositol-3 kinase, Akt, SYK, glycogen synthase kinase-3α/β, cytosolic phospholipase A, and p38 expression, which are signal transduction molecules expressed by platelets, and consequently suppressed αIIbβ3 activity and thromboxane A generation. Taken together, PBE showed strong antiplatelet effects and may be used to block thrombosis- and platelet-mediated cardiovascular diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567598 | PMC |
| http://dx.doi.org/10.3746/pnf.2023.28.3.328 | DOI Listing |
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