AI Article Synopsis
- A new process analytical technology system is introduced, combining a lab-scale reactor with a liquid-jet cell for real-time monitoring of complex synthesis processes through X-ray absorption spectroscopy (XAS).
- The system successfully tracked the preparation of sulfonate-stabilized CaCO particles while analyzing changes in calcium speciation as conditions varied over time.
- By quantitatively resolving composition changes in the synthesis process, this technology enhances our understanding of how process attributes relate to product quality and performance on a molecular level.
Article Abstract
Process analytical technologies are widely used to inform process control by identifying relationships between reagents and products. Here, we present a novel process analytical technology system for XAS on multiphase multicomponent synthesis processes based on the combination of a conventional lab-scale agitated reactor with a liquid-jet cell. The preparation of sulfonate-stabilized CaCO particles from polyphasic Ca(OH) dispersions was monitored in real time by Ca K-edge XAS to identify changes in Ca speciation in the bulk solution/dispersion as a function of time and process conditions. Linear combination fitting of the spectra quantitatively resolved composition changes from the initial conversion of Ca(OH) to the Ca(R-SO) surfactant to the ultimate formation of CaCO·Ca(R- SO) particles. The system provides a novel tool with strong chemical specificity for probing multiphase synthesis processes at a molecular level, providing an avenue to establishing the relationships between critical quality attributes of a process and the quality and performance of the product.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571072 | PMC |
| http://dx.doi.org/10.1021/acs.iecr.3c02540 | DOI Listing |
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