AI Article Synopsis
- Chronic kidney disease (CKD) and acute kidney injury (AKI) are complex conditions characterized by changes in kidney function, with varying patient outcomes and treatment responses despite specific histopathological markers.
- The Kidney Precision Medicine Project (KPMP) aims to create detailed cellular and molecular maps of kidney health and disease, identifying disease subtypes that traditional methods might miss.
- KPMP integrates diverse data from kidney biopsies, utilizing advanced techniques such as pathomics and proteomics, to improve understanding and future care strategies for patients with CKD and AKI.
Article Abstract
Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes defined clinically by serial measures of kidney function. Each condition possesses strong histopathologic associations, including glomerular obsolescence or acute tubular necrosis, respectively. Despite such characterization, there remains wide variation in patient outcomes and treatment responses. Precision medicine efforts, as exemplified by the Kidney Precision Medicine Project (KPMP), have begun to establish evolving, spatially anchored, cellular and molecular atlases of the cell types, states, and niches of the kidney in health and disease. The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples. This perspective outlines the structure of the KPMP, its approach to the integration of these diverse datasets, and its major outputs relevant to future patient care.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922684 | PMC |
| http://dx.doi.org/10.1053/j.ajkd.2023.08.015 | DOI Listing |
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