Event-driven hybrid pixel detectors with nanosecond time resolution have opened up novel pathways in modern ultrafast electron microscopy, for example in hyperspectral electron-energy loss spectroscopy or free-electron quantum optics. However, the impinging electrons typically excite more than one pixel of the device, and an efficient algorithm is therefore needed to convert the measured pixel hits to real single-electron events. Here we present a robust clustering algorithm that is fast enough to find clusters in a continuous stream of raw data in real time. Each tuple of position and arrival time from the detector is continuously compared to a buffer of previous hits until the probability of a merger with an old event becomes irrelevant. In this way, the computation time becomes independent of the density of electron arrival and the algorithm does not break the operation chain. We showcase the performance of the algorithm with a 'timepix' camera in two regimes of electron microscopy, in continuous beam emission and laser-triggered femtosecond mode.
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http://dx.doi.org/10.1016/j.ultramic.2023.113864 | DOI Listing |
Neural Netw
January 2025
Tsinghua University, Beijing, China. Electronic address:
Artificial neural networks (ANNs) can help camera-based remote photoplethysmography (rPPG) in measuring cardiac activity and physiological signals from facial videos, such as pulse wave, heart rate and respiration rate with better accuracy. However, most existing ANN-based methods require substantial computing resources, which poses challenges for effective deployment on mobile devices. Spiking neural networks (SNNs), on the other hand, hold immense potential for energy-efficient deep learning owing to their binary and event-driven architecture.
View Article and Find Full Text PDFSci Rep
December 2024
Research and Development, ICU Medical India LLP, Chennai, Tamil Nadu, 600006, India.
In clustered cognitive radio sensor networks (CRSNs), availability of free channels, spectrum sensing and energy utilization during clustering and cluster head (CH) selection is essential for fairness of time and event-driven data traffic. The existing multi-hop routing protocols in CRSNs generally adopt a perfect spectrum sensing which is not same in the practical spectrum sensing of nodes in real networks. High imbalance in residual energy between the selected CHs negatively impacts the delivery of data packets.
View Article and Find Full Text PDFACS Chem Biol
October 2024
Center for Discovery in Cancer Research, Department of Biochemistry and Biomedical Sciences, Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4L8.
Recent advances in the field of translational chemical biology use diverse "proximity-inducing" synthetic modalities to elicit new modes of "event driven" pharmacology. These include mechanisms of targeted protein degradation and immune clearance of pathogenic cells. Heterobifunctional "chimeric" compounds like Proteolysis TArgeting Chimeras (PROTACs) and Antibody Recruiting Molecules (ARMs) leverage these mechanisms, respectively.
View Article and Find Full Text PDFCell Chem Biol
September 2024
Arvinas, Inc., 5 Science Park, New Haven, CT 06511, USA. Electronic address:
This minireview explores the burgeoning field of targeted protein degradation (TPD) and its promising applications in neuroscience and clinical development. TPD offers innovative strategies for modulating protein levels, presenting a paradigm shift in small-molecule drug discovery and therapeutic interventions. Importantly, small-molecule protein degraders specifically target and remove pathogenic proteins from central nervous system cells without the drug delivery challenges of genomic and antibody-based modalities.
View Article and Find Full Text PDFBioorg Chem
December 2024
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
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