Cisplatin metallodrugs have been widely used in the treatment of multiple cancers over the last years. Nevertheless, its limited effectiveness, development of acquired drug resistances, and toxic effects decrease nowadays their application in clinical settings. Aiming at improving their features, investigations have been oriented towards the coupling of cisplatin to nanocarriers, like liposomes or inorganic nanoparticles. Moreover, these systems can be further developed to allow targeted co-delivery of drugs. In this review, we describe the major nanosystems and the optimal analytical strategies for their assessment. Finally, we describe the main biological effects of these metallodrug conjugates and the available approaches for their study.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpba.2023.115760 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modular comparison of untargeted metabolomics processing steps.
Anal Chim Acta
January 2025
Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Austria; BOKU University, Vienna, Dept. IFA-Tulln, Institute of Bioanalytics and Agro-Metabolomics, Tulln, Austria.
Background: Untargeted metabolomics requires robust and reliable strategies for data processing to extract relevant information form the underlying raw data. Multiple platforms for data processing are available, but the choice of software tool can have an impact on the analysis. This study provides a comprehensive evaluation of four workflows based on commonly used metabolomics software tools: XCMS, Compound Discoverer, MS-DIAL, and MZmine.
View Article and Find Full Text PDFTargeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.
Cell Chem Biol
January 2025
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified NB cells, Aurora kinase A (Aurora-A) binds to and stabilizes N-Myc, resulting in elevated protein levels. Here, we demonstrate that targeted protein degradation of Aurora-A decreases N-Myc levels.
View Article and Find Full Text PDFIntegrating Particle Motion Tracking into Thermal Gel Electrophoresis for Label-Free Sugar Sensing.
ACS Sens
January 2025
Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, Michigan 48202, United States.
Bioanalytical sensors are adept at quantifying target analytes from complex sample matrices with high sensitivity, but their multiplexing capacity is limited. Conversely, analytical separations afford great multiplexing capacity but typically require analyte labeling to increase sensitivity. Here, we report the development of a separation-based sensor to sensitively quantify unlabeled polysaccharides using particle motion tracking within a microfluidic electrophoresis platform.
View Article and Find Full Text PDFComparative immunogenicity assessment of biosimilar natalizumab to its reference medicine: a matching immunogenicity profile.
Front Immunol
January 2025
Polpharma Biologics S.A., Gdansk, Poland.
Background: Biosimilar natalizumab (biosim-NTZ) is the first biosimilar monoclonal antibody of reference natalizumab (ref-NTZ) for treatment of relapsing forms of multiple sclerosis (MS). Within the totality of evidence for demonstration of biosimilarity, immunogenicity assessments were performed in healthy subjects and patients with relapsing-remitting MS (RRMS) to confirm a matching immunogenicity profile between biosim-NTZ and ref-NTZ.
Methods: Immunogenicity of biosim-NTZ versus ref-NTZ was evaluated in two pivotal clinical studies.
Advancements and Applications of Conjugated Polyelectrolytes and Conjugated Oligoelectrolytes in Bioanalytical and Electrochemical Contexts.
JACS Au
December 2024
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
In the past decade, conjugated oligoelectrolytes (COEs) and conjugated polyelectrolytes (CPEs) have emerged at the forefront of active materials in bioanalytical and electrochemical settings due to their unique electronic and ionic properties. These materials possess π-conjugated backbones with ionic functionalities at the ends of their side chains, granting them water solubility and facilitating their processability, exploration, and applications in aqueous environments. In this perspective, the basis for evaluating their figures of merit in selected bioanalytical and electrochemical contexts will be provided and contextualized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!