NMR screening methods based on F spin-spin relaxation time (F-T) were applied to fluorinated compounds bound to human serum albumin. Diflunisal and fleroxacin (the fluorinated compounds) contain two and three fluorine atoms per molecule, respectively, and are suitable as the model system for F NMR analysis. It was shown that F-T was more sensitive in monitoring the binding affinity to the target protein than F spin-lattice relaxation time (F-T). The comparisons of F signal intensities acquired at different echo times using F-T pulse sequence were also shown to be an effective means of assessing complex formation for fluorinated compounds.
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