AI Article Synopsis
- The study focuses on the environmental impacts of nanoplastics (NPs), highlighting their interference with reproductive and adipose stromal cells and potential cardiovascular risks.
- Researchers investigated how NPs affect aortic endothelial cells (AOC) by measuring their interaction with these cells, cell growth, and oxidative stress responses.
- Findings showed that NPs significantly increase metabolic activity and Vascular Endothelial Growth Factor (VEGF) production in AOC, while also disrupting the redox status, indicating a negative impact on normal cell function.
Article Abstract
Plastic is an important environmental issue and a more critical aspect concerns plastic fragments, mainly in term of nanoplastics (NPs). We demonstrated that NPs interfere with reproductive and adipose stromal cells. Since several research underlined an increased cardiovascular risk due to NPs, present study was undertaken to investigate their effect on aortic endothelial cells (AOC). We explored the specificity of their interaction with endothelial cells, quantifying their load in treated cells. Then, NPs effect was assessed on cell growth, generation of free radicals and antioxidant defence. Our data demonstrate that NPs colocalize with AOC. We found a significant (p < 0.01) increase both in metabolic activity and Vascular Endothelial Growth Factor (VEGF) production (p < 0.01). Redox status appeared to be disrupted (p < 0.05) by NPs. Taken together, the normal function of cultured AOC appeared negatively affected by AOC. Since NPs have been detected in blood, our present data appear of particular interest.
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| http://dx.doi.org/10.1016/j.etap.2023.104294 | DOI Listing |
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