Time-to-boundary (TtB) is a popular balance metric that identifies minimum reaction times available to correct balance challenges during quiet standing. Minimum event criteria is a critical methodological consideration to determine physiologically relevant TtB outcomes yet selection methodology appears inconsistent and/or vaguely defined across studies. This study aimed to identify a robust, objective methodology to select meaningful TtB outcomes. Ninety-seven healthy adults stood quietly on a force platform with eyes open and feet together. Anterior-posterior (AP) and medial-lateral (ML) center-of-pressure data from 150 s were utilized to compute a TtB series. The MATLAB findpeaks function identified minima with and without a time delay following selected events and/or a vertical axis threshold. An individualized time delay excluded excessively large values that hold no clinically relevant information, and this effect was enhanced by a vertical threshold at 22 s. The absolute minimum TtB was unaffected by any findpeaks criteria. The recommendations implicated by these results will help improve clarity and consistency among TtB studies, thereby enhancing the applicability of clinical findings.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.humov.2023.103151 | DOI Listing |
Nat Rev Clin Oncol
December 2024
Department of Neurosurgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Leptomeningeal metastatic disease (LMD), encompassing entities of 'meningeal carcinomatosis', neoplastic meningitis' and 'leukaemic/lymphomatous meningitis', arises secondary to the metastatic dissemination of cancer cells from extracranial and certain intracranial malignancies into the leptomeninges and cerebrospinal fluid. The clinical burden of LMD has been increasing secondary to more sensitive diagnostics, aggressive local therapies for discrete brain metastases, and improved management of extracranial disease with targeted and immunotherapeutic agents, resulting in improved survival. However, owing to drug delivery challenges and the unique microenvironment of LMD, novel therapies against systemic disease have not yet translated into improved outcomes for these patients.
View Article and Find Full Text PDFJ Clin Lipidol
October 2024
Department of Cardiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China. Electronic address:
Orthop J Sports Med
September 2024
Department of Sports Medicine of Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China.
BMJ Health Care Inform
August 2024
Universite de Montreal, Montreal, Quebec, Canada
Background: Older patients with diabetic kidney disease (DKD) often do not receive optimal pharmacological treatment. Current clinical practice guidelines (CPGs) do not incorporate the concept of personalised care. Clinical decision support (CDS) algorithms that consider both evidence and personalised care to improve patient outcomes can improve the care of older adults.
View Article and Find Full Text PDFHeart Rhythm
December 2024
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!