Neuronal HLH-30/TFEB modulates thermoresistance and longevity in .

The conserved autophagy transcription factor HLH-30/TFEB is a well-established modulator of lifespan in several mechanistically-distinct longevity paradigms in . While various tissues contribute differentially to organismal lifespan, neurons are particularly interesting as they can mediate adaptive response to environmental and proteostatic stresses. Using carefully-designed neuronal-specific reconstitution of HLH-30 in loss of function mutants, we found a role for neuronal HLH-30 in modulating longevity and heat stress response via neurotransmission-mediated peripheral mitochondrial fragmentation. Altogether, we demonstrated new links between neuronal HLH-30 function, thermoresistance and organismal aging.