AI Article Synopsis
- The essential oil from (L.) Maton, a plant in the Zingiberaceae family, has been shown to inhibit the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro.
- Using a bio-guided fractionation method, researchers isolated specific fractions and tested their effects individually, finding that the oxygenated fraction exhibited significant inhibitory activity against both enzymes.
- The bioactivity of the essential oil is linked to a combination of oxygenated terpenes, including α-terpinyl acetate and 1,8-cineole, which work together to enhance the oil's overall effectiveness.
Article Abstract
(L.) Maton (Zingiberaceae family) is a plant traditionally used in Ayurvedic and Chinese medicine. In this work, the essential oil of was found to inhibit the enzymes AChE (62.6% of inhibition, IC 24.9 μg/mL) and BChE (55.8% of inhibition, IC 25.9 μg/mL) by performing an in vitro colorimetric assay using the Ellman method. A bio-guided fractionation approach was used to isolate fractions/pure compounds that were tested individually to evaluate their activity. The resulting oxygenated fraction was found to be active against both AChE (percentage inhibition 42.8%) and BChE (percentage inhibition 63.7%), while the hydrocarbon fraction was inactive. The activity was attributed to a pool of oxygenated terpenes (α-terpinyl acetate, 1,8-cineole, linalool, linalyl acetate, and α-terpineol) that synergistically contributed to the overall activity of the essential oil.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575282 | PMC |
| http://dx.doi.org/10.3390/plants12193463 | DOI Listing |
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